Top 399 Senior staff scientist Jobs in Alameda Ca

Staff / Senior Scientist, Bioconjugation Chemistry
Glyphic Biotechnologies —Berkeley, CA
- $123,000 - $187,575 a year
- Full-time
- Doctor of Philosophy
- Senior level
- 4 years
- Paid parental leave
- Health insurance
Quick Apply
Staff / Senior Scientist, Assay Development (Chemistry)
Glyphic Biotechnologies —Berkeley, CA
- $123,000 - $187,575 a year
- Full-time
- Doctor of Philosophy
- Senior level
- 4 years
- Paid parental leave
- Health insurance
Quick Apply
Senior Scientist
Roche —Pleasanton, CA
- $111,000 - $206,500 a year
- Online Application
- Bachelor of Science
- 3 years
- Master's degree
Senior Scientist I (In Vivo Pharmacology)
Exelixis, Inc. —Alameda, CA
- $127,500 - $180,500 a year
- Weekends as needed
- Bachelor of Science
- Office
- Microsoft Office
- Paid holidays
- Disability insurance
2d
Hydrogeologist - Mid- or Senior Level
Montgomery & Associates —Oakland, CA
- $8,000 - $9,500 a year
- Full-time
- Microsoft Access
- 6 years
- Office
- AD&D insurance
- Disability insurance
Quick Apply
7d
Principal Environmental Professional or Biologist
Onterris —Oakland, CA
- $150,000 - $180,000 a year
- Full-time
- 11+ years
- Master's degree
- Bachelor's degree
Sr Principal, Executive Operations - Ads & Data Platforms
Disney Entertainment and ESPN Product & Technology —San Francisco, CA
- $227,200 - $304,700 a year
- 11+ years
- Bachelor's degree
- Organizational skills
Senior Project Manager
Abbott Laboratories —Alameda, CA
- $114,000 - $228,000 a year
- Full-time
- 7 years
- Senior level
- Associate's degree
- Health insurance
- Tuition reimbursement
Senior Staff Scientist - Quantum
Vector Atomic —Pleasanton, CA
- $175,000 - $215,000 a year
- Full-time
- 11+ years
- Electrical experience
- Doctor of Philosophy
- Paid parental leave
- Paid holidays
Quick Apply
Writer 2
Stanford University —Stanford, CA
- Part-time
- Remote
- 5 years
- Research
- Mid-level
13d
Life Sciences Operator, Lead
Anthropic —San Francisco, CA
- $300,000 - $320,000 a year
- Hybrid work
- 7 years
- Office
- Bachelor's degree
- Parental leave
- Flexible schedule
10d
Life Science Research Professional 1 (1 year fixed-term)
Stanford University —Stanford, CA
- Full-time
- Computer literacy
- Maintenance
- Bachelor's degree
6d
IT Business Relationship Manager
Information Technology Senior Management Forum —Alameda, CA
- $130,700 - $261,300 a year
- Full-time
- Engineering
- Office
- 8 years
- Health insurance
- Tuition reimbursement
Senior Executive Assistant
Altos Labs —Redwood City, CA
- $159,400 - $204,400 a year
- Microsoft Excel
- Microsoft Outlook
- Office
Senior Manager, Quality Systems - Lingo (on-site)
Abbott Laboratories —Alameda, CA
- $130,700 - $261,300 a year
- Full-time
- 7 years
- Bachelor's degree
- Recruiting
- Health insurance
- Tuition reimbursement
Scientist / Senior Scientist, Structural Biology
Amgen —South San Francisco, CA
- $142,518.65 - $192,819.35 a year
- 3 years
- Bachelor's degree
- Doctor of Philosophy
- Disability insurance
- Health insurance
5d
SENIOR INDUSTRIAL HYGIENIST
Department of Public Health —Contra Costa County, CA
- $10,630 - $14,203 a month
- Online Application
- Hybrid work
- Travel
- Senior level
- Professional Engineer
Senior Clinical Lab Scientist
Sequoia Hospital —Redwood City, CA
- $78.61 - $97.93 an hour
- PRN
- Hospital
- 5 years
- Bachelor of Science
4d
Industry Principal, Life Sciences
Anthropic —San Francisco, CA
- $450,000 - $550,000 a year
- Hybrid work
- HIPAA
- 11+ years
- Office
- Parental leave
- Flexible schedule
Senior Principal Scientist (Antibody Drug Conjugate)
Exelixis, Inc. —Alameda, CA
- $169,500 - $239,500 a year
- Email
- Bachelor of Science
- Laboratory experience
- 8 years
- Paid holidays
- Disability insurance
12d

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senior staff scientist jobs near alameda ca

Staff / Senior Scientist, Bioconjugation Chemistry

Glyphic Biotechnologies
Berkeley, CA

Quick Apply

Job Details

Full-time
$123,000 - $187,575 a year

Benefits

Stock options
Paid parental leave
Health insurance
Dental insurance
Paid time off
Parental leave
Vision insurance

Qualifications

High-performance liquid chromatographs
Chemical separation processes
Capillary electrophoresis
Handling nucleic acids
Organic synthesis
Cross-functional communication
Mass spectrometry
Molecular analysis

Full Job Description

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

We are seeking a Senior or Staff Scientist, Bioconjugation to join our Chemistry team at a pivotal stage in assay development. Reporting to the Senior Director of Chemistry, you will be a hands-on expert who designs, develops, and executes bioconjugation strategies for peptide and oligonucleotide components that are central to our single-molecule proteome sequencing assay.

The ideal candidate brings deep expertise in protein and peptide bioconjugation, site-specific chemical modification of amino acid sidechains, and oligonucleotide-biomolecule conjugation, with a track record of working in complex, multi-component systems (e.g., ADCs, therapeutic bioconjugates, or new bioconjugated components for assays). A successful candidate will have an innovative method-development mindset and will effectively build new approaches to making bioconjugates. This individual will thrive in a cross-functional environment where chemical solutions must be tightly integrated into assay design.

This role offers the unique opportunity to develop first-in-class conjugation chemistry that enables single-molecule protein sequencing.

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

What you'll do

Bioconjugation strategies:

Partner with sample prep and assay development to screen and select conjugation chemistries for peptides and oligonucleotides that enable single molecule protein sequencing
Design bioconjugation workflows using NHS-ester chemistry, maleimides, isothiocyanate chemistry, and click chemistry (CuAAC, SPAAC, IEDDA)
Prepare bioconjugation reagents to enable studies from proof-of-concept through prototype-kitting.

Peptide chemistry:

Develop labeling strategies based on Edman Chemistry
Develop and apply selective C-terminal and N-terminal conjugation chemistries
Develop site-specific labeling strategies for amino acid sidechains (Cys, Lys, Arg, Tyr, Trp, His, Asp/Glu) on native peptides. Screen protecting groups to enhance amino acid signal in the protein sequencing assay
Enable on-bead workflow to label and release peptides for interrogation in the sequencing assay

Synthesize, characterize, and scale:

Synthesize and purify peptide and oligonucleotide conjugates for assay testing
Characterize conjugation efficiency, purity, and stability using tools such as HPLC, LC-MS/MS, NMR, CE, UV/Vis, and FTIR
Scale conjugate synthesis from R&D quantities to prototype-grade supply for internal testing, with attention to reproducibility, shelf-life, and fit-for-purpose quality

Collaborate and document:

Work cross-functionally with sample preparation, assay integration, and reagent manufacturing teams to troubleshoot conjugation failures and optimize workflows
Contribute to intellectual property development through invention disclosures
Maintain rigorous experimental documentation in Confluence and laboratory notebooks; author and maintain SOPs for new conjugation methods

What you need

Required:

MS or PhD in organic chemistry, chemical biology, biochemistry, or a related field
Industry experience in bioconjugation chemistry, with demonstrated ability to independently design, develop, and troubleshoot conjugation workflows
- MS/PhD with 8+/6+ years of experience (for Staff Scientist)
- MS/PhD with 6+/4+ years of experience (for Senior Scientist)
Deep expertise in protein and/or peptide bioconjugation: NHS esters, maleimides, click chemistries (CuAAC, SPAAC, IEDDA), isothiocyanate coupling, and related bioorthogonal approaches
Experience with site-specific amino acid sidechain chemistry beyond maleimide chemistry (e.g. Cys, Lys, Arg, Tyr, Trp, Asp/Glu) for application in multistep workflows
Track record developing novel blocking groups and conducting SAR studies to optimize blocking group performance and selectivity
Proficiency in analytical characterization: HPLC method development, LC-MS/MS for conjugate analysis, UV/Vis, and CE
Method-development mindset: history of building and adapting new chemical approaches rather than executing established protocols
Demonstrated ability to function as an independent contributor and collaborative partner in a cross-functional team setting

Nice to have:

Hands-on experience with solid-phase peptide synthesis (SPPS), including protecting group strategies beyond standard Fmoc/Boc and selective on-resin modifications
Experience with peptide C-terminal chemistry manipulation methods: thioester formation, native chemical ligation, or photoredox/iridium-catalyzed C-terminal labeling
Familiarity with oligonucleotide chemistry and oligo-conjugation techniques (ITC, phosphoramidite modifications, click coupling to nucleic acids)
Experience with scalable surface chemistry methods for flow cells or solid-phase supports
Familiarity with statistical and DOE-based experimental design for chemistry optimization
Prior experience in an early-stage biotech or tools/diagnostics company

We're looking for a teammate that:

Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.
Treats obstacles as problems to be creatively solved, not reasons something can't be done.
Applies sound judgment to the best available information, testing, learning, and iterating.
Shares early and directly when assumptions change, results are unclear, or timelines are at risk.

What you can expect from this role

Work environment:

Collaborative culture where your ideas and expertise are valued
Direct impact on product development and company direction

Professional growth:

Learn from a diverse team of world-class scientists and engineers
Contribute to first-of-their kind technologies, high-impact publications, and patents

Compensation

Estimated Base Salary $123,000 - $187,575

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Quick Apply

Refine Your Search

senior staff scientist jobs in alameda ca

Staff / Senior Scientist, Bioconjugation Chemistry

Staff / Senior Scientist, Assay Development (Chemistry)

Senior Scientist

Senior Scientist I (In Vivo Pharmacology)

Hydrogeologist - Mid- or Senior Level

Principal Environmental Professional or Biologist

Sr Principal, Executive Operations - Ads & Data Platforms

Senior Project Manager

Senior Staff Scientist - Quantum

Writer 2

Life Sciences Operator, Lead

Life Science Research Professional 1 (1 year fixed-term)

IT Business Relationship Manager

Senior Executive Assistant

Senior Manager, Quality Systems - Lingo (on-site)

Scientist / Senior Scientist, Structural Biology

SENIOR INDUSTRIAL HYGIENIST

Senior Clinical Lab Scientist

Industry Principal, Life Sciences

Senior Principal Scientist (Antibody Drug Conjugate)

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