Top 478 Senior applied scientist Jobs in Belmont Ca

Senior / Staff Scientist, Assay Automation
Clear Labs —San Carlos, CA
- $120,000 - $150,000 a year
- Full-time
- 8 years
- Doctor of Philosophy
- US work authorization
- AD&D insurance
- Disability insurance
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Senior Applied Scientist
Microsoft —Mountain View, CA
- $119,800 - $261,000 a year
- Full-time
- Hybrid work
- Background check
- Doctoral degree
- Computer Science
Senior Scientist
Vivodyne —San Francisco, CA
- $115,000 - $160,000 a year
- Full-time
- Analysis skills
- Continuous improvement
- Doctor of Philosophy
Senior Data Scientist
Tonal —San Francisco, CA
- $165,000 - $190,000 a year
- Full-time
- Remote
- 3 years
- SQL
- Senior level
- Disability insurance
- Health insurance
Senior Applied Scientist
Samsara —San Francisco, CA
- $170,170 - $286,000 a year
- Computer Science
- Bachelor of Science
- 3 years
- Health insurance
- Parental leave
3d
Senior Data Scientist, Applied AI
Rippling —San Francisco, CA
- $138,000 - $230,000 a year
- Full-time
- Hybrid work
- Office
- 3 years
- SQL
11d
Senior Data Scientist
Northbeam —San Francisco, CA
- $170,000 - $200,000 a year
- 8 hour shift
- Remote
- Computer Science
- 5 years
- Math
- Paid parental leave
- Paid holidays
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Senior Data Scientist - Experimentation & Measurement
Sony Interactive Entertainment —San Mateo, CA
- $178,900 - $268,300 a year
- 5 years
- Master's degree
- SQL
- Wellness program
- Health insurance
Senior Postmarket Surveillance Data Scientist
Abbott Laboratories —Alameda, CA
- $90,000 - $180,000 a year
- Full-time
- Computer Science
- Office
- SQL
- Health insurance
- Tuition reimbursement
Senior Applied AI/ML Scientist
NobleAI —San Francisco, CA
- $190,000 - $220,000 a year
- Full-time
- Remote
- Azure
- AWS
- Doctor of Philosophy
- Paid holidays
- Disability insurance
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Senior Applied Scientist
Adobe —San Jose, CA
- $142,700 - $270,950 a year
- Full-time
- Fair chance
- Experience equivalent to degree accepted
- Senior level
Senior Data Scientist - Product
Apollo.io —San Francisco, CA
- $160,000 - $200,000 a year
- Remote
- SQL
- Analysis skills
- Continuous improvement
Quick Apply
Senior Data Scientist
Rundoo —Redwood City, CA
- $201,000 - $248,000 a year
- Full-time
- Remote
- 5 years
- Senior level
- Middle school
- Paid holidays
- Health insurance
Senior Applied Scientist, Applied AI Solutions GTM
Amazon Development Center U.S., Inc. —Mountain View, CA
- $167,100 - $260,000 a year
- Full-time
- 5 years
- Master's degree
- Doctor of Philosophy
- AD&D insurance
- Health insurance
Senior AI Scientist
Intuit —Mountain View, CA
- $165,500 - $243,500 a year
- Computer Science
- Bachelor of Science
- Research
Sr Applied Scientist - Allocation Optimization - Remote
Cystems Logic Inc —San Jose, CA
- Contract
- Remote
- Math
- Senior level
- Python
Quick Apply
1d
Sr Clinical Scientist
iRhythm Technologies, Inc. —San Francisco, CA
- $150,000 - $180,000 a year
- Full-time
- Remote
- Medicine
- English
- Doctor of Philosophy
- Travel reimbursement
- Paid parental leave
Quick Apply
3d
Senior Data Scientist II - Core Delivery
Instacart —San Francisco, CA
- $218,000 - $230,000 a year
- Remote
- 7 years
- SQL
- Analysis skills
Quick Apply
Senior Scientist - Translational Safety & Risk Sciences (TSRS)
Amgen —San Francisco, CA
- $129,228.90 - $174,839.10 a year
- Remote
- Medicine
- 3 years
- Bachelor's degree
- Disability insurance
- Health insurance
Applied Scientist
Adobe —San Jose, CA
- $120,700 - $238,600 a year
- Full-time
- Computer Science
- Master's degree
- Analysis skills

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Senior / Staff Scientist, Assay Automation

Clear Labs -
San Carlos, CA

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Job Details

Full-time
$120,000 - $150,000 a year

Benefits

Stock options
AD&D insurance
Disability insurance
Health insurance
Dental insurance
Employee assistance program
Vision insurance

Qualifications

Laboratory experiment design
Defect resolution root cause analysis
System troubleshooting
Hypothesis testing
Design of experiments
Molecular diagnostic equipment
Assay development
Molecular diagnostic testing
Inferential statistics
Quality standards in production
Regression analysis
Biomedical regulatory compliance
Simulation analysis
Automated liquid handling systems
Bioinformatics data analysis
Statistical significance testing
Debugging
Statistical analysis tools
Failure analysis
Illumina
Molecular analysis

Full Job Description

About Clear Labs

Clear Labs (CL) harnesses the power of next-generation sequencing (NGS) to simplify complex diagnostics for clinical and applied markets. By creating a fully automated platform that brings together DNA sequencing, robotics, and cloud-based analytics, Clear Labs democratizes genomics applications to deliver better clarity. Clear Labs’ turnkey platform accelerates outcomes and improves accuracy from food-borne pathogens to infectious diseases.

Position Summary

You will own the end-to-end performance of NGS assays running on Hamilton Platforms for Illumina-based sequencing assays, from wet lab execution through data interpretation. The work directly determines assay reliability in clinical use and is foundational to scaling our diagnostic platform.

This role is leveled Senior or Staff based on demonstrated scope, autonomy, and track record of shipping NGS assays into regulated environments. We will calibrate level during the interview process.

This is a hands-on role, not a managerial one. It is best suited for scientists who have repeatedly debugged failed NGS experiments and can trace issues across assay design, automated execution, and downstream data.

How This Role Operates

Partners daily with Assay Development, Automation Engineering, Bioinformatics, Manufacturing, and Regulatory / Quality.
Owns assay performance decisions on assigned product workstreams; signs off on experimental designs, root-cause findings, and verification study conclusions within scope.
Expected to escalate cross-functional tradeoffs and regulatory implications to the Director of Assay Development.

Location: San Carlos, CA

Primary Responsibilities

Assay Development (Core)

Troubleshoot and optimize full NGS workflows: extraction, fragmentation, end repair, ligation, library prep, target enrichment or amplification, pooling, and sequencing.
Identify root causes of assay failures and implement durable, documented fixes.
Redesign assay components for robustness, scalability, and reproducibility under production conditions.
Lead verification, characterization, and reagent qualification studies that drive assay decisions.
Own measurable improvements in assay reliability, variability, and yield on assigned workstreams.

Data Analysis and Experimental Design

Analyze sequencing data and run metrics to diagnose performance issues across the wet-to-dry interface.
Design experiments using DOE, regression, and hypothesis testing; quantify variance contributions.
Build and maintain quantitative performance metrics that characterize assay variability and stability.
Conduct reagent stability studies and lot-to-lot qualification.

Automation Integration

Develop and troubleshoot assays running on liquid handling automation (Hamilton or equivalent).
Partner with automation engineers to translate manual protocols into validated automated workflows.
Diagnose and resolve automation-related sources of variability.

Regulatory and Quality

Execute work under design controls and a quality management system (ISO 13485 or equivalent).
Contribute to analytical validation activities (LoD, precision, specificity, reproducibility, interference).
Apply structured problem-solving tools (FMEA, CAPA, change control) as part of routine work.

Requirements

Applicants must be currently authorized to work in the United States on a full-time basis; no visa sponsorship is available for this position.

PhD in molecular biology, genomics, bioengineering, or related field, OR equivalent industry experience defined as 8+ years in NGS assay development with at least one shipped IVD, LDT, or commercially deployed assay.
Demonstrated hands-on experience developing Illumina NGS assays through to production or clinical use.
Track record of leading end-to-end root-cause investigations of complex assay failures.
Hands-on experience developing or troubleshooting assays on liquid handling automation (Hamilton or equivalent).
Experience working under ISO 13485, FDA design controls, or a comparable regulated quality system.
Working proficiency in R, Python, JMP, or equivalent for sequencing data analysis and statistical experimental design (DOE, ANOVA, regression, variance decomposition).

Preferred Experience

IVD or LDT assay development for oncology, infectious disease, or similar clinical indications.
Hands-on experience with FFPE and/or cfDNA sample types.
Experience with hybrid capture target enrichment and/or amplicon-based panel design.
Named contribution to a 510(k), De Novo, PMA, or equivalent regulatory submission.
Experience integrating assays with downstream bioinformatics pipelines.

What Success Looks Like in the First 12 MonthsHow We Will Evaluate Candidates

Technical depth interview: walk through a real NGS assay failure you debugged end-to-end, including the data you used to localize the root cause.
Experimental design exercise: design a study to characterize a defined source of variability under stated constraints.
Cross-functional simulation: navigate a tradeoff between assay performance, automation feasibility, and regulatory impact.

Benefits

Salary range: $120,000–$150,000
Medical, dental, and vision insurance
Employer-Sponsored Basic Life/AD&D, Long Term Disability
Employee Assistance Program (EAP)
Flexible Time Off
Stock Option Plan
Lunch stipend for days at headquarters

Notice of E-Verify Participation: Clear Labs participates in the federal E-Verify program to confirm the identity and employment eligibility of all newly hired employees. For more information, please review the E-Verify Participation Poster (English/Spanish) and the Right to Work Poster (English/Spanish).

Disclaimer

The above job description is intended to describe the general nature and level of work being performed by individuals assigned to this position. It is not intended to be an exhaustive list of all duties, responsibilities, and skills required. Responsibilities and duties may change or be adjusted to meet the needs of the company, and additional duties may be assigned as necessary. The job description is subject to change at any time at the discretion of the Company.

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Refine Your Search

senior applied scientist jobs in belmont ca

Senior / Staff Scientist, Assay Automation

Senior Applied Scientist

Senior Scientist

Senior Data Scientist

Senior Applied Scientist

Senior Data Scientist, Applied AI

Senior Data Scientist

Senior Data Scientist - Experimentation & Measurement

Senior Postmarket Surveillance Data Scientist

Senior Applied AI/ML Scientist

Senior Applied Scientist

Senior Data Scientist - Product

Senior Data Scientist

Senior Applied Scientist, Applied AI Solutions GTM

Senior AI Scientist

Sr Applied Scientist - Allocation Optimization - Remote

Sr Clinical Scientist

Senior Data Scientist II - Core Delivery

Senior Scientist - Translational Safety & Risk Sciences (TSRS)

Applied Scientist

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