Top 14 Principal scientist Jobs in Carlsbad, Ca

Principal Scientist
Merck KGaA —Carlsbad, CA
- $113,000 - $169,600 a year
- Bachelor of Science
- 11+ years
- Analysis skills
- Health insurance
- Paid time off
Principal Scientist / Senior Principal Scientist
Arisan Therapeutics, Inc —Carlsbad, CA
- $150,000 - $205,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- US work authorization
- Paid holidays
- Relocation assistance
Quick Apply
7d
Principal Scientist, Analytical Development
Artiva Biotherapeutics —San Diego, CA
- $170,000 - $185,000 a year
- Full-time
- Management
- Doctor of Philosophy
- Mentoring
- Paid holidays
- Disability insurance
Quick Apply
10d
Principal Scientist - BioProcess Development
Wacker Chemie AG —San Diego, CA
- $140,000 - $155,000 a year
- Online Application
- Bachelor of Science
- Analysis skills
- Bachelor's degree
- Paid parental leave
- Paid holidays
PRINCIPAL SCIENTIST- (Protein Immunotherapy)
The Scripps Research Institute —San Diego, CA
- $120,000 - $150,000 a year
- Management
- Bachelor's degree
- Doctor of Philosophy
- Free parking
- Health savings account
Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis
IQVIA —Carlsbad, CA
- $125,800 - $350,300 a year
- Full-time
- Remote
- 5 years
- English
- Analysis skills
- Work from home
9d
Principal Research Associate/ Toxicology Study Coordinator
Ionis Pharmaceuticals, Inc. —Carlsbad, CA
- $110,847 - $142,160 a year
- Full-time
- Hybrid work
- Microsoft Excel
- Microsoft Outlook
- Bachelor of Science
Quick Apply
Principal Product Economist - Poker
Zynga —Carlsbad, CA
- $133,000 - $183,000 a year
- Full-time
- 5 years
- SQL
- Psychology
- Commuter assistance
- Paid parental leave
Quick Apply
8d
Principal Investigator- Vaccines (Oceanside, CA)**
Profound Research —Oceanside, CA
- Medicine
- Patient monitoring
- Clinic
- Health insurance
- Paid time off
Quick Apply
Principal Bioinformatician
Hologic —San Diego, CA
- $129,700 - $216,200 a year
- Azure
- AWS
- Analysis skills
Principal, Pricing Outcomes and Economics
MedImpact Healthcare Systems —San Diego, CA
- $132,323 - $240,828 a year
- Weekends as needed
- Computer literacy
- Bachelor of Science
- 8 years
- Paid holidays
- Disability insurance
1d

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Principal Scientist / Senior Principal Scientist
Arisan Therapeutics, Inc —Carlsbad, CA
The position combines scientific leadership with external-study oversight, regulatory support, technical writing, program planning, budget and timeline…
$150,000 - $205,000 a year
Quick Apply
7d
Senior Hazards/Hazardous Materials Analyst
Aspen Environmental Group —California
Requires a minimum of a bachelor’s degree in chemical or civil engineering, environmental science, planning, or related field; a Master's degree is preferred.
$125,000 - $150,000 a year
Quick Apply

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Principal Research Scientist, Product Development & Innovation - Nutrition - Columbus, OH
Abbott Laboratories —Columbus, OH
The position is responsible for developing talent, providing technical direction, and delivering products that meet targets for performance, quality, cost, and…
$129,300 - $258,700 a year
1d

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principal scientist jobs near carlsbad, ca

Principal Scientist

Merck KGaA -
Carlsbad, CA

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Job Details

$113,000 - $169,600 a year

Benefits

Health insurance
Paid time off

Qualifications

Team development
Managing teams of scientists
Mentoring
Process validation (IQ/OQ/PQ)
Leading team collaboration initiatives
Verification of laboratory test methods
GMP for research safety and compliance
Test validation method
Cross-functional team management
Cross-functional communication

Full Job Description

Work Your Magic with us! Start your next chapter and join MilliporeSigma.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role:

MilliporeSigma is seeking a skilled and motivated Analytical Scientist with expertise in validation of analytical methods to support a Viral Vector CDMO Facility in Carlsbad, CA. The successful candidate will be responsible for conducting advanced analytical analyses, transferring and validating analytical methods to support all Phases of GMP Viral Vector client programs and ensuring the accuracy and reliability of test results. The Quality Scientist position, like all positions at MilliporeSigma, will have a willingness to contribute to the overall success of the company by assisting in many areas beyond specific job duties.

Key Responsibilities:

Perform advanced analytical testing such as qPCR, ddPCR, HPLC, CE-SDS, and ELISA.
Lead and own large, cross-functional analytical programs (method development, validation/transfer, QC support) across multiple products or programs.
Define and drive the method validation/transfer strategy, including relevant considerations (e.g. ddPCR, qPCR, HPLC, ELISA, CE-SDS, FTIR, Gel Electrophoresis, etc.) with auditable documentation.
Mentor and develop scientists; provide technical leadership in data integrity, statistics, and interpretation of complex analytical data.
Lead root-cause investigations for OOS/OOT events; implement CAPAs with measurable effectiveness; drive continuous improvement.
Oversee instrument qualification (IQ/OQ/PQ/PM) and routine maintenance for critical platforms; ensure audit readiness.
Manage project planning, risk, and cross-site coordination; communicate status to leadership and clients/partners.
Develop and maintain SOPs, work instructions, and templates for compendial and non-compendial methods; ensure ALCOA+ data integrity.
Document and investigate out-of-specification (OOS) and out-of-trend (OOT) results, applying critical thinking to identify root causes and corrective actions
Train and mentor junior scientists, providing technical guidance and coaching.
Develop and review technical documentation (SOPs, work instructions, protocols, reports, transfer protocols).
Ensure compliance with cGMP, regulatory requirements, and ICH guidelines.
Drive continuous improvement initiatives to increase laboratory efficiency and analytical capability.
Collaborate cross-functionally with Quality Assurance, Manufacturing, Process and Analytical Development, Facilities & Engineering, global network and external partners and clients.
Promote a culture of safety, quality, learning, and knowledge sharing.
Physical Attributes:
Work in analytical testing lab.
Bend, stoop, squat, crawl, kneel, climb, or reach overhead.
Wear required PPE such as safety glasses, gloves, masks, and close-toed shoes.

Who You Are:

You are an accomplished Analytical Scientist with 15+ years of experience, adept at leading method validation, transfer, and optimization programs in a cGMP/FDA-regulated environment. You excel in performing advanced analytical testing (qPCR, ddPCR, HPLC, CE-SDS, ELISA) and in designing studies, analyzing complex data, and delivering actionable conclusions on schedule. You are a strong technical leader who mentors junior scientists, authors and reviews protocols and reports, and drives cross-functional collaboration across QA, Manufacturing, and external partners. You maintain rigorous data integrity, investigate OOS/OOT results with root-cause analysis, and implement corrective actions to improve quality and efficiency. You bring a Biologics/Virology background or depth in microbial testing and QA release testing, coupled with excellent scientific communication and a continuous-improvement mindset. Your focus is on ensuring test accuracy, instrument reliability, and a culture of safety, quality, and knowledge sharing.

Minimum Qualifications:

Education: BS or MS in Chemistry, Analytical Science, or related field (or equivalent experience).
Experience: 15+ years in GLP/GMP analytical environments; proven leadership in method validation/transfer; experience mentoring cross-functional teams.

Preferred Qualifications:

Knowledge and technical expertise with biologics analytical techniques, method validation, and assay testing.
Academic or industry-based background in Virology.
Strong critical and analytical thinking skills for effective problem-solving and outcome improvement.
Experience mentoring and leading junior associates.
Knowledge of cGMP manufacturing and quality systems within an FDA-regulated environment and ICH quality guidelines.
Technical Skills: Proficiency in analytical techniques (e.g., ELISA, HPLC/UPLC, qPCR/ddPCR, spectroscopy, cell-based assays); method validation/transfer; data trending and statistics; instrument maintenance; basic programming or data analysis tools a plus.
Regulatory/Quality: Knowledge of cGMP, ICH guidelines, and QA/QC systems; experience with regulatory submissions and deviations/CAPAs.
Soft Skills: Excellent scientific communication (written and oral), problem-solving, collaboration, adaptability, and mentoring ability.
Desired: Biologics/Virology background; experience with microbial testing, QA release testing, and GMP documentation

Pay Range for this position: $113,000-$169,600

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here.

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!

Apply Now

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principal scientist jobs in carlsbad, ca

Principal Scientist

Principal Scientist / Senior Principal Scientist

Principal Scientist, Analytical Development

Principal Scientist - BioProcess Development

PRINCIPAL SCIENTIST- (Protein Immunotherapy)

Associate Principal, Indirect Treatment Comparison (ITC), Evidence Synthesis

Principal Research Associate/ Toxicology Study Coordinator

Principal Product Economist - Poker

Principal Investigator- Vaccines (Oceanside, CA)**

Principal Bioinformatician

Principal, Pricing Outcomes and Economics

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