Top 2802 Scientist Jobs in Castro Valley Ca

Senior Scientist/Principal Scientist, Translational Immunotherapy
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- Management
- 5 years
- Master's degree
- Commuter assistance
- Health insurance
Quick Apply
12d
Lab Technician - Mechanical Sample Preparation
JH Technologies, Inc. —Fremont, CA
- $60,000 - $80,000 a year
- Full-time
- Customer service
- Analysis skills
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
11d
Staff Clinical Laboratory Scientist
Machaon Diagnostics —Berkeley, CA
- $50 - $100 an hour
- 8 hour shift
- Laboratory experience
- Bachelor's degree
- In-person
- Profit sharing
- Health insurance
Quick Apply
Clinical Data Scientist - AI Trainer
DataAnnotation —San Ramon, CA
- $50 - $100 an hour
- Part-time
- Remote
- Computer Science
- English
- Mid-level
- Flexible schedule
Quick Apply
Scientist III (Immunology Discovery, Barreira Lab)
Tailored Management —South San Francisco, CA
- $48.89 - $83.23 an hour
- 8 hour shift
- Analysis skills
- Doctor of Philosophy
- In-person
- Health insurance
- Dental insurance
Quick Apply
1d
Chemistry Lab Analyst (ICP-MS)
Ascend Clinical —Sunnyvale, CA
- $30 - $32 an hour
- Full-time
- Mid-level
- Math
- Cleaning
- Paid holidays
- Disability insurance
Quick Apply
CLS - Quality Assurance / Quality Control - Clinical Laboratory Scientist
Lighthouse Lab Services —Richmond, CA
- $65 - $75 an hour
- Contract
- Mid-level
- Analysis skills
- Bachelor's degree
- Dental insurance
- 401(k) 4% Match
Quick Apply
Scientist, iPSC Model Development
Kelly Services —San Francisco, CA
- $45 - $75 an hour
- Full-time
- Mid-level
- Doctor of Philosophy
- US work authorization
- Commuter assistance
- Health savings account
Quick Apply
Clinical Lab Scientist - WCMC Clinical Laboratory Services - Per Diem - 8 Hour - Variable Shift
John Muir Health —Walnut Creek, CA
- $65.04 - $87.78 an hour
- 8 hour shift
- Bachelor of Science
- Bachelor's degree
- Entry level
Bioinformatics Scientist
Thermo Fisher Scientific —Pleasanton, CA
- $82,800 - $95,000 a year
- Full-time
- Background check
- Computer Science
- Bachelor of Science
- Commuter assistance
- Paid parental leave
Research Associate or Associate Scientist, Genome Engineer
Conception —Berkeley, CA
- Full-time
- Research
- Master's degree
- Doctor of Philosophy
- Health insurance
Molecular Biologist - Academic Graduate Appointee
Lawrence Livermore National Laboratory —Livermore, CA
- $6,748 - $7,718 a month
- Full-time
- Background check
- Bachelor of Science
- Pass drug screening
- Relocation assistance
- 401(k)
1d
Research associate or Sr Research associate
GeneGenieDx —Pleasanton, CA
- $71,000 - $100,000 a year
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
Scientist I - III
Rani Therapeutics —Fremont, CA
- $80,000 - $179,000 a year
- Bachelor of Science
- Bachelor's degree
- Senior level
Quick Apply
Biology Scientist
Apostle —Pleasanton, CA
- $75,000 - $110,000 a year
- Full-time
- No experience needed
- Doctor of Philosophy
- In-person
Research Assistant/Research Associate
Frontage Laboratories —Hayward, CA
- $62,400 - $80,000 a year
- Full-time
- Bachelor of Science
- Maintenance
- Bachelor's degree
- Disability insurance
- Health insurance
Quick Apply
Research Associate I (Protein Science & Analytics)
EVERY™ —San Francisco Bay Area, CA
- $75,000 - $85,000 a year
- Analysis skills
- Bachelor's degree
- US work authorization
- Free parking
- Paid holidays
Quick Apply
5d
Research Associate (RL Environments)
Anthrogen —San Francisco, CA
- $120,000 - $200,000 a year
- Full-time
- Bachelor of Science
- Research
- Bachelor's degree
Quick Apply
Laboratory Technician (Part-time)
San Mateo County Community College District —San Mateo, CA
- Part-time
- Laboratory
- Mid-level
- University
- Paid holidays
- 403(b)
Research Associate, Molecular Biology
Ansa Biotechnologies —Emeryville, CA
- $88,200 - $96,600 a year
- Bachelor of Science
- Mid-level
- Analysis skills
- Health insurance
- Dental insurance
4d

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Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Biosciences
San Carlos, CA

Quick Apply

Job Details

Full-time
$130,000 - $160,000 a year
12 days ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Biology
Biotechnology
Technical documentation
Formulation chemistry
Cell Biology
Master's degree
Doctor of Philosophy
Pharmaceutical company experience
In vivo studies
Pharmaceutical research experience

Full Job Description

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Senior Scientist/Principal Scientist to work on our lead oncology program, leading the path from hit-to-lead generation to DC nomination for an off-the-shelf, memory-recall-based immunotherapy: designing, executing, and interpreting primary-cell assays that establish mechanism, potency, and safety. This role will report to the CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Drive the identification, engineering, and functional optimization of lead immunotherapeutic candidates from early discovery through to DC nomination.
Design and execute cell-based assays (e.g., multi-parameter flow cytometry, cytotoxicity, cytokine profiling) to evaluate memory-recall, T-cell activation, and target engagement.
Characterize primary human T-cells and PBMCs (e.g. phenotyping) both prior and following response to stimulation.
Navigate challenges in working with, and characterizing, polyclonal T-cell responses, and is aware of how these challenges differ from monoclonal T-cell products.
Develop and support assays to forecast off-target events that leverage cross-reactivity as a method for overcoming antigen tolerance.
Benchwork to include profiling antigen-specific T-cells using IFN-γ ELISpot, and activation-induced marker (AIM) assays, and intracellular cytokine staining, with matrix/pool deconvolution design.
Develop assays to forecast off-target events in a system that leverages cross-reactivity as a method for overcoming antigen tolerance.
Oversee tetramer/dextramer and multimer staining, including executing high-avidity, peptide-MHC (pMHC) assays and employing DNA-barcoded multimers.
Running standard cytotoxicity readouts (e.g. IncuCyte).
Interpreting immunopeptidomics (LC-MS/MS HLA-ligand) data generated by collaborators/CROs and translate it into epitope-processing and presentation decisions.
Investigate the biological mechanisms (MoA) underlying the therapy’s ability to drive vigorous, durable anti-tumor memory.
Oversee in vivo and ex vivo studies to define the therapeutic's efficacy, pharmacodynamics (PD), and pharmacokinetics (PK).
Partner with the R&D team to de-risk assets prior to IND-enabling studies.
Manage direct reports/vendor/collaborators, present data to cross-functional teams, and author technical reports and regulatory documents to support governance reviews.
Interpret, analyze, present, and properly record data.
Prepare documents and presentations that encompass project progression.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses.
Working knowledge of HLA biology, supertypes, population coverage logic, and HLA-matched experimental systems.
Immunotherapy drug development experience is a must.
Prior cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.
Familiarity with adjuvants (TLR agonists, saponins, poly-ICLC) and how formulation shapes the T-cell response.
Experience with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and familiarity with readouts both in flight and downstream of animal studies.
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

Please tell us about your experience with cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.

Experience:

T cell biology : 5 years (Required)

Location:

San Carlos, CA 94070 (Preferred)

Work Location: In person

Quick Apply

Refine Your Search

scientist jobs in castro valley ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Lab Technician - Mechanical Sample Preparation

Staff Clinical Laboratory Scientist

Clinical Data Scientist - AI Trainer

Scientist III (Immunology Discovery, Barreira Lab)

Chemistry Lab Analyst (ICP-MS)

CLS - Quality Assurance / Quality Control - Clinical Laboratory Scientist

Scientist, iPSC Model Development

Clinical Lab Scientist - WCMC Clinical Laboratory Services - Per Diem - 8 Hour - Variable Shift

Bioinformatics Scientist

Research Associate or Associate Scientist, Genome Engineer

Molecular Biologist - Academic Graduate Appointee

Research associate or Sr Research associate

Scientist I - III

Biology Scientist

Research Assistant/Research Associate

Research Associate I (Protein Science & Analytics)

Research Associate (RL Environments)

Laboratory Technician (Part-time)

Research Associate, Molecular Biology

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