Top 463 Senior scientist Jobs in Half Moon Bay, Ca

Senior Scientist/Principal Scientist, Translational Immunotherapy
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- Management
- 5 years
- Master's degree
- Commuter assistance
- Health insurance
Quick Apply
9d
Senior Scientist I, Oncology Research
CytomX Therapeutics, Inc. —South San Francisco, CA
- $155,000 - $175,000 a year
- Full-time
- Hybrid work
- Doctor of Philosophy
- Travel
- Senior level
Sr. Scientist (Synthetic Chemistry)
Hongene Biotech Corporation —Union City, CA
- From $115,000 a year
- Full-time
- Mid-level
- Doctor of Philosophy
- US work authorization
- Relocation assistance
- Health insurance
Quick Apply
Senior/Principal Scientist, Peptide Medicinal Chemistry
Stealth Biotech —San Mateo, CA
- $150,000 - $200,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- In-person
- Health insurance
- Dental insurance
Quick Apply
3d
Senior Manager, Operations
Coherent Corp. —Sunnyvale, CA
- Overtime
- Microsoft Word
- 7 years
- Engineering
- Paid time off
Senior Analytical Scientist
Advantage Technical —Menlo Park, CA
- $85,000 - $100,000 a year
- Temporary
- 3 years
- Doctor of Philosophy
- Senior level
- Health savings account
- AD&D insurance
Quick Apply
Lead, Senior, or Principal Biologist
SWCA Environmental Consultants —Half Moon Bay, CA
- $97,344 - $166,133 a year
- Online Application
- Master's degree
- 8 years
- Supervising experience
- Opportunities for advancement
Scientist / Senior Scientist, Protein Engineering
Kodiak Sciences Inc. —Palo Alto, CA
- Full-time
- Doctor of Philosophy
- Senior level
- Communication skills
Senior Research Associate
Altos Labs —Redwood City, CA
- $109,200 - $140,000 a year
- Bachelor of Science
- Engineering
- Bachelor's degree
Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling
CALICO —South San Francisco, CA
- $160,000 - $197,000 a year
- 3 years
- Analysis skills
- Doctor of Philosophy
Scientist / Senior Scientist, Structural Biology
Amgen —South San Francisco, CA
- $142,518.65 - $192,819.35 a year
- 3 years
- Bachelor's degree
- Doctor of Philosophy
- Disability insurance
- Health insurance
Decision Scientist Senior
Salesforce —San Francisco, CA
- $148,500 - $223,900 a year
- Full-time
- Computer Science
- 5 years
- Mentoring
- Paid parental leave
- Disability insurance
Scientist / Senior Scientist, Ads Systems
roblox —San Mateo, CA
- $248,740 - $322,820 a year
- Full-time
- Office
- US work authorization
- Senior level
Senior Scientist, Antibody Discovery
Merck —San Francisco, CA
- $131,400 - $206,800 a year
- Full-time
- Master's degree
- Analysis skills
- Bachelor's degree
- Paid holidays
- Health insurance
Senior Apps Applied Scientist
Apple —Cupertino, CA
- $184,700 - $324,800 a year
- Computer Science
- 3 years
- Analysis skills
- Employee stock purchase plan
- Health insurance
3d
Machine Learning Scientist / Senior Machine Learning Scientist
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Doctor of Philosophy
- In-person
Health AIML Senior Research Scientist
Apple —Cupertino, CA
- $216,200 - $394,000 a year
- Computer Science
- Doctor of Philosophy
- Senior level
- Employee stock purchase plan
- Health insurance
4d
Senior Field Scientist
Alembic —San Francisco, CA
- $160,000 - $185,000 a year
- Full-time
- AWS
- Travel
- Mentoring
Scientist/Sr. Scientist
Osanni Bio, Inc. —San Carlos, CA
- $140,000 - $170,000 a year
- Full-time
- Doctor of Philosophy
- Team management
- Mentoring
Quick Apply
Senior Associate Scientist, Analytical Operations
Gilead Sciences —Foster City, CA
- $126,820 - $164,120 a year
- Full-time
- Master's degree
- Bachelor's degree
- Training & development
- Health insurance
- Dental insurance

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Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Biosciences
San Carlos, CA

Quick Apply

Job Details

Full-time
$130,000 - $160,000 a year
9 days ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Biology
Biotechnology
Technical documentation
Formulation chemistry
Cell Biology
Master's degree
Doctor of Philosophy
Pharmaceutical company experience
In vivo studies
Pharmaceutical research experience

Full Job Description

Senior Scientist/Principal Scientist, Translational Immunotherapy

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Senior Scientist/Principal Scientist to work on our lead oncology program, leading the path from hit-to-lead generation to DC nomination for an off-the-shelf, memory-recall-based immunotherapy: designing, executing, and interpreting primary-cell assays that establish mechanism, potency, and safety. This role will report to the CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Drive the identification, engineering, and functional optimization of lead immunotherapeutic candidates from early discovery through to DC nomination.
Design and execute cell-based assays (e.g., multi-parameter flow cytometry, cytotoxicity, cytokine profiling) to evaluate memory-recall, T-cell activation, and target engagement.
Characterize primary human T-cells and PBMCs (e.g. phenotyping) both prior and following response to stimulation.
Navigate challenges in working with, and characterizing, polyclonal T-cell responses, and is aware of how these challenges differ from monoclonal T-cell products.
Develop and support assays to forecast off-target events that leverage cross-reactivity as a method for overcoming antigen tolerance.
Benchwork to include profiling antigen-specific T-cells using IFN-γ ELISpot, and activation-induced marker (AIM) assays, and intracellular cytokine staining, with matrix/pool deconvolution design.
Develop assays to forecast off-target events in a system that leverages cross-reactivity as a method for overcoming antigen tolerance.
Oversee tetramer/dextramer and multimer staining, including executing high-avidity, peptide-MHC (pMHC) assays and employing DNA-barcoded multimers.
Running standard cytotoxicity readouts (e.g. IncuCyte).
Interpreting immunopeptidomics (LC-MS/MS HLA-ligand) data generated by collaborators/CROs and translate it into epitope-processing and presentation decisions.
Investigate the biological mechanisms (MoA) underlying the therapy’s ability to drive vigorous, durable anti-tumor memory.
Oversee in vivo and ex vivo studies to define the therapeutic's efficacy, pharmacodynamics (PD), and pharmacokinetics (PK).
Partner with the R&D team to de-risk assets prior to IND-enabling studies.
Manage direct reports/vendor/collaborators, present data to cross-functional teams, and author technical reports and regulatory documents to support governance reviews.
Interpret, analyze, present, and properly record data.
Prepare documents and presentations that encompass project progression.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses.
Working knowledge of HLA biology, supertypes, population coverage logic, and HLA-matched experimental systems.
Immunotherapy drug development experience is a must.
Prior cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.
Familiarity with adjuvants (TLR agonists, saponins, poly-ICLC) and how formulation shapes the T-cell response.
Experience with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and familiarity with readouts both in flight and downstream of animal studies.
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

Please tell us about your experience with cancer-vaccine or general vaccine development experience, including peptide, protein-subunit, or nucleic-acid modalities, spanning antigen selection through in vivo immunogenicity.

Experience:

T cell biology : 5 years (Required)

Location:

San Carlos, CA 94070 (Preferred)

Work Location: In person

Quick Apply

Refine Your Search

senior scientist jobs in half moon bay, ca

Senior Scientist/Principal Scientist, Translational Immunotherapy

Senior Scientist I, Oncology Research

Sr. Scientist (Synthetic Chemistry)

Senior/Principal Scientist, Peptide Medicinal Chemistry

Senior Manager, Operations

Senior Analytical Scientist

Lead, Senior, or Principal Biologist

Scientist / Senior Scientist, Protein Engineering

Senior Research Associate

Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling

Scientist / Senior Scientist, Structural Biology

Decision Scientist Senior

Scientist / Senior Scientist, Ads Systems

Senior Scientist, Antibody Discovery

Senior Apps Applied Scientist

Machine Learning Scientist / Senior Machine Learning Scientist

Health AIML Senior Research Scientist

Senior Field Scientist

Scientist/Sr. Scientist

Senior Associate Scientist, Analytical Operations

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