Top 1293 Research scientist Jobs in Los Altos, Ca

Senior/Principal Scientist, Peptide Medicinal Chemistry
Stealth Biotech —San Mateo, CA
- $150,000 - $200,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- In-person
- Health insurance
- Dental insurance
Quick Apply
4d
Temp to Permanent Entry-Level Data Manager/Clinical Research Coordinator Associate
Stanford University Department of Bioengineering —Stanford, CA
- $35 - $38 an hour
- Temporary
- Bachelor of Science
- HIPAA
- University
Quick Apply
Lab Technician - Mechanical Sample Preparation
JH Technologies, Inc. —Fremont, CA
- $60,000 - $80,000 a year
- Full-time
- Customer service
- Analysis skills
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
8d
Research Scientist - AI Trainer
DataAnnotation —California
- $50 - $100 an hour
- Part-time
- Remote
- Computer Science
- English
- Mid-level
- Flexible schedule
Quick Apply
Temporary CRCA
Stanford University —Palo Alto, CA
- $38 - $40 an hour
- Temporary
- Hybrid work
- Spanish
- HIPAA
- Mid-level
Quick Apply
Research Scientist
Megagon Labs —Mountain View, CA
- Full-time
- Computer science
- Computer Science
- Java
- Health insurance
- Dental insurance
Research Scientist
Stanford University —Stanford, CA
- $108,002 - $128,138 a year
- Full-time
- Hybrid work
- Mid-level
- 3 years
- SQL
5d
Research Scientist
Scaled Cognition —Mountain View, CA
- Full-time
- Hybrid work
- Senior level
Quick Apply
Research Nurse 1
Stanford University —Stanford, CA
- $114,953 - $148,232 a year
- Full-time
- Hybrid work
- CPR Certification
- Nursing
- RN License
Senior Research Associate (SRA)/ Scientist I
Evommune, Inc. —Palo Alto, CA
- $109,000 - $150,000 a year
- Weekends as needed
- 5 years
- Maintenance
- Mid-level
- Paid parental leave
- Disability insurance
Quick Apply
9d
Student Researcher, BS/MS, Fall 2026
Google —San Bruno, CA
- $98,000 - $131,000 a year
- Computer Science
- Bachelor of Science
- English
- Paid holidays
- Health insurance
Research Scientist
Adobe —San Jose, CA
- $120,700 - $238,600 a year
- Full-time
- Computer Science
- Doctor of Philosophy
- Mentoring
Research Data Analyst (12-Month Fixed-Term)
Stanford University —Stanford, CA
- Extended hours
- Computer literacy
- Maintenance
- Ability to lift 50 pounds
Research Scientist
AccuraGen —Milpitas, CA
- Full-time
- Doctor of Philosophy
- 1 year
- Senior level
- Health insurance
- Dental insurance
Quick Apply
Research associate or Sr Research associate
GeneGenieDx —Pleasanton, CA
- $71,000 - $100,000 a year
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
Associate Scientist, R&D
Natera —San Carlos, CA
- $50 - $57 an hour
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Commuter assistance
- Health insurance
Research Scientist, Demography and Survey Sciences
Meta —Menlo Park, CA
- $147,000 - $208,000 a year
- Writing skills
- Mid-level
- Analysis skills
Life Science Research Professional 1
Stanford University —Stanford, CA
- $32.58 - $38.48 an hour
- Extended hours
- Ability to lift 50 pounds
- Analysis skills
- University
Research Data Analyst 2
Stanford University —Stanford, CA
- Full-time
- Hybrid work
- Writing skills
- Mid-level
- Microsoft Office
- Health insurance
- Dental insurance
1d
ML Data - Research Scientist
Apple —Cupertino, CA
- $184,700 - $277,600 a year
- Computer Science
- Bachelor of Science
- Bachelor's degree
- Employee stock purchase plan
- Health insurance

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Senior/Principal Scientist, Peptide Medicinal Chemistry

Stealth Biotech
San Mateo, CA

Quick Apply

Job Details

Full-time
$150,000 - $200,000 a year
4 days ago

Benefits

Health insurance
Dental insurance
401(k)
Vision insurance

Qualifications

AI models
Project team coordination
Computational research
Teamwork
Automation
High-performance liquid chromatographs
Medicinal chemistry
Doctor of Philosophy
Pharmaceutical analysis
Project delivery management
Leading team collaboration initiatives
Chemistry
Research data analysis
Cross-functional team management
Pharmaceutical research experience
Python
Cross-functional communication
Nuclear magnetic resonance (NMR) spectroscopy
Mass spectrometry
Molecular analysis

Full Job Description

The role

The candidate will lead peptide medicinal chemistry on one or more discovery programs, from hit triage and affinity maturation through developability optimization to candidate selection.

The role carries end-to-end responsibility for the DMTA cycle: defining the design hypothesis, directing synthesis through contract research organizations, interpreting the resulting data, and returning it to the design models. It is a hands-on position that combines individual technical contributions with project leadership. Close collaboration with our AI team is central to the role: translating model output into designs that can be made and tested, returning experimental results in a form the models can learn from, and helping shape what the models are asked to predict next.

Key responsibilities

Design and program leadership

Set and defend the medicinal chemistry strategy for assigned peptide programs, from hits to development candidates.
Drive affinity maturation campaigns.
Optimize developability alongside potency: proteolytic stability, solubility, permeability, half-life extension, and route-of-administration constraints.
Design off-target examination strategies in collaboration with biology and DMPK.
Represent chemistry in portfolio reviews and before the leadership team, with clear go/no-go recommendations and the data supporting them.

DMTA execution, automation, and throughput

Run a high-cadence DMTA cycle: design molecules, prioritize what gets made, and reduce the time from hypothesis to result.
Establish the data discipline that makes the cycle learnable — structured capture of sequences, structures, assay results, and decisions; and feedback to models.

CRO and external management

Own the relationship with peptide synthesis and analytical CROs.
Prepare and review synthesis requests and characterization data.

Working with the platform

Partner with machine-learning colleagues.
Curate the chemistry knowledge on which the platform depends.

Requirements

PhD in organic chemistry, medicinal chemistry, biochemistry, or a closely related field.
Extensive experience in peptide medicinal chemistry within a drug discovery setting, including demonstrated success in affinity maturation and in optimizing ADME and developability properties of peptides.
Strong synthetic and analytical chemistry skills: solid-phase and solution-phase peptide synthesis, macrocyclization chemistries, non-natural and modified building blocks, conjugation, and the analytical methods required to characterize the products (LC-MS, HRMS, NMR, prep-HPLC, chiral and purity analysis).
Experience in a project-leading role — a discovery project or workstream led end to end, with accountability for direction, cross-functional coordination, and outcomes.
High-throughput and automation experience applied to the DMTA cycle — parallel synthesis, high-throughput analytics, and associated data handling.
Fluency in structure-based and property-based design.
Clear scientific communication, both written and verbal, across chemistry, biology, and computational audiences.

Desirable

Working knowledge of agentic workflows.
Experience establishing synthetic and assay workflows from scratch.
Familiarity with computational tools: docking, molecular dynamics, structure prediction, cheminformatics, or scripting in Python.
Experience with peptide half-life extension strategies or with oral peptide delivery.
Track record in a relevant modality — macrocyclic peptides, constrained peptides, peptide–drug conjugates, etc.
Experience taking a peptide program through IND-enabling studies or working with CMC and process chemistry colleagues on scale-up.
Publications, granted patents, or a preclinical or clinical asset you can speak to.

What we offer

Ownership over the chemistry strategy of a young portfolio, and influence over the design platform itself.
A short path from decision to experiment — a small team, short decision paths, and direct access to leadership.
Close, day-to-day exposure to computational and machine-learning approaches to molecular design.
Competitive salary, early-stage equity, and a full benefits package.

About us

We are an early-stage biotechnology company currently in stealth mode. We have developed proprietary machine-learning models and are applying them to our peptide therapeutics pipeline.

Pay: $150,000.00 - $200,000.00 per year

Benefits:

401(k)
Dental insurance
Health insurance
Vision insurance

Work Location: In person

Quick Apply

Refine Your Search

research scientist jobs in los altos, ca

Senior/Principal Scientist, Peptide Medicinal Chemistry

Temp to Permanent Entry-Level Data Manager/Clinical Research Coordinator Associate

Lab Technician - Mechanical Sample Preparation

Research Scientist - AI Trainer

Temporary CRCA

Research Scientist

Research Scientist

Research Scientist

Research Nurse 1

Senior Research Associate (SRA)/ Scientist I

Student Researcher, BS/MS, Fall 2026

Research Scientist

Research Data Analyst (12-Month Fixed-Term)

Research Scientist

Research associate or Sr Research associate

Associate Scientist, R&D

Research Scientist, Demography and Survey Sciences

Life Science Research Professional 1

Research Data Analyst 2

ML Data - Research Scientist

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