Top 3739 Senior system engineer Jobs in San Francisco Bay Area Ca

Senior Software Engineer, Scientific System of Record
Lila Sciences —San Francisco, CA
- $144,000 - $240,000 a year
- Remote
- Azure
- Computer Science
- System design
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Senior Structural Engineer / Project Manager
SEDR Consulting —Oakland, CA
- From $70 an hour
- Full-time
- Office
- Quality control
- Mentoring
Quick Apply
1d
Optics Engineer
Confidential Posting —San Francisco, CA
- $110,000 - $160,000 a year
- Full-time
- Travel
- US work authorization
- In-person
- Health insurance
- Dental insurance
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Senior Mechanical Engineer – Accelerator Systems
AcceleRAD Technologies —Hayward, CA
- $105,000 - $125,000 a year
- Full-time
- Bachelor of Science
- Ability to lift 50 pounds
- Analysis skills
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3d
Senior Quality Engineer
Real Staffing —San Mateo, CA
- $140,000 a year
- 6 years
- Senior level
- Leadership
- Dental insurance
- Vision insurance
Senior Weblogic/DevOps Engineer (Automation & Middleware)
AgreeYa Solutions —Oakland, CA
- $60 - $65 an hour
- Contract
- In-person
- Senior level
- Communication skills
- Health insurance
- Dental insurance
Quick Apply
9d
SENIOR ORACLE FINANCIALS ENGINEER - REMOTE WITHIN CALIFORNIA
University of California Office of the President —Oakland, CA
- $150,000 - $175,000 a year
- Full-time
- Remote
- Background check
- System design
- SQL
1d
Senior Construction Project Manager
A|B Construction —Oakland, CA
- $125,000 - $250,000 a year
- Full-time
- Background check
- Construction site
- Mid-level
- Health insurance
- Dental insurance
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Sr. Quality Engineer
Inland Metal Technologies —Hayward, CA
- $85,000 - $115,000 a year
- Full-time
- Mid-level
- Microsoft Office
- US work authorization
- Health insurance
- Dental insurance
Quick Apply
Network AND Telecommunications Engineer, ON-SITE, Information Technology, Full-Time, Days
MarinHealth Medical Center —San Rafael, CA
- $54.32 - $81.48 an hour
- 8 hour shift
- Computer Science
- Hospital
- 5 years
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3d
Senior Software Engineer - Salesforce
Delta Dental —Oakland, CA
- $93,445 - $202,465 a year
- Full-time
- Hybrid work
- Background check
- Computer Science
- Bachelor of Science
- Paid holidays
- Health insurance
Sr. Engineer: TI DSP / Real-Time Systems & Audio (iRDK)
Experis —San Francisco, CA
- $100 an hour
- Contract
- Computer Science
- Senior level
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Senior Software Engineer (Oracle Cloud EPM)
Delta Dental —Oakland, CA
- $93,445 - $202,465 a year
- Full-time
- Hybrid work
- Background check
- Computer science
- Oracle
- Paid holidays
- Health insurance
10d
Senior Staff Data Center Operations Engineer, GPU Hardware Architecture
Crusoe —San Francisco, CA
- $179,000 - $218,000 a year
- Full-time
- Bachelor of Science
- Analysis skills
- Training & development
- Commuter assistance
- Paid parental leave
Quick Apply
Senior Aerodynamic Engineer (Turbomachinery & Gas Turbines)
Belcan —Brisbane, CA
- $103.37 an hour
- Doctor of Philosophy
- Mentoring
- Organizational skills
Quick Apply
13d
Senior Dynamics Engineer (Turbomachinery & Gas Turbines)
Belcan —Brisbane, CA
- $101.92 an hour
- Analysis skills
- Organizational skills
- Software development
Quick Apply
13d
Senior Structural Engineer (Turbomachinery & Gas Turbines)
Belcan —Brisbane, CA
- $100.96 - $101.92 an hour
- Analysis skills
- Organizational skills
- Software development
Quick Apply
13d
Senior Electrical Engineer
Everforth, Cybercoders —Novato, CA
- $140,000 - $180,000 a year
- Full-time
- 6 years
- Master's degree
- Analysis skills
- Dental insurance
- Paid time off
Quick Apply
Sr. Product Quality Engineer
Experis —Alameda, CA
- $60 - $65 an hour
- Contract
- Training & development
- Senior level
Quick Apply
2d
Sr. Transmission Line Engineer
NV5 —California
- $125,000 - $165,000 a year
- Full-time
- Bachelor of Science
- Quality control
- Mentoring
- Health insurance
- Dental insurance

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senior system engineer jobs near san francisco bay area ca

Senior Software Engineer, Scientific System of Record

Lila Sciences
San Francisco, CA

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Job Details

$144,000 - $240,000 a year

Qualifications

AI models
Index optimization
Data model design
Software engineering
Data modeling projects
Improving system uptime or availability
IT system monitoring
Data retrieval time improvement
AI tools proficiency
Scalable systems
Schema design
JavaScript frameworks
SQL
Collaboration with product development teams
Systems engineering
Production monitoring
Developing and maintaining backend systems
Front-end component implementation
Back-end integration
System tuning
Query management
Cloud monitoring
TypeScript
Python
Cross-functional communication
System performance monitoring

Full Job Description

Your Impact at LILA

Join us in shaping the future of science! We are seeking Senior Software Engineers with full stack experience to join our Scientific System of Record Team (SSR), where you'll collaborate with software engineers, lab scientists, and machine learning engineers to build cutting-edge tools for automated scientific analysis and more. If you thrive in a collaborative, fast-paced environment and bring best practices in git, development workflows, and user-centered design, we want to hear from you!

About The Team

The Scientific System of Record Team (SSR) builds the memory layer for Lila's operations. It answers two questions:what did we plan to build? and what actually happened? These systems connect scientific intent to physical reality. Together with the data and automation teams, their systems ensure reproducibility and close the Design-Build-Test-Learn (DBTL) loop.

What You'll Be Building

Lab Execution and Scientific Workflows: Build systems that model scientific intent, experiment planning, protocol execution, sample and asset state, operational events, and results capture across complex lab workflows.
User Interfaces and APIs: Design and implement high-quality, secure, and well-documented UIs and APIs that support scientists, automation systems, ML workflows, and AI-driven applications.
Application Development: Build front-end and backend services with a focus on performance, maintainability, and reliability.
Data and System Modeling: Develop domain models, schemas, indexes, and data contracts across SQL, NoSQL, vector databases, data lakehouses, and other scientific data systems.
Reliability, Performance, and Scale: Diagnose bottlenecks, improve system performance, and contribute to observability, reliability, and operational excellence for production systems.
Cloud and Infrastructure: Use AWS services, Kubernetes, and modern DevOps practices to build and deploy production-grade systems.
Cross-Functional Collaboration: Partner with scientists, ML researchers, platform engineers, data engineers, automation teams, and product managers to translate scientific and operational needs into software.
Engineering Quality: Contribute to architecture discussions, code reviews, testing practices, documentation, and shared engineering standards.

What You'll Need To Succeed

Bachelor's or Master's degree in Computer Science, Engineering, or related field.
4-6+ years of engineering experience building and deploying large-scale systems in production. You must be strong in either front-end or backend.
Strong expertise in at least one of the following areas, with the ability to work across the stack: front-end engineering, backend engineering, or data modeling and system design.
TypeScript, React, and Python: Strong experience building modern applications with React and TypeScript; Python experience is strongly preferred.
Application and API Development: Experience designing, building, and maintaining APIs, services, and application components with a focus on reliability, performance, and maintainability.
Databases and Data Modeling: Experience with SQL and at least one of NoSQL, vector databases, search systems, or data lakehouse architectures; familiarity with schema design, indexing, and query optimization.
Production Systems: Experience operating production software, including debugging, monitoring, performance tuning, and improving reliability over time.
Collaboration: Strong communication skills and a track record of working cross-functionally with engineers, product teams, scientists, or other domain experts.
Problem Solving: Ability to take ownership of ambiguous technical problems, make practical trade-offs, and deliver maintainable solutions.
Hands-on experience using AI coding assistants or AI-augmented engineering workflows to improve productivity.

Bonus Points For

Cloud and DevOps: Hands-on experience with AWS, GCP, or Azure; strong understanding of Kubernetes, containerization, infrastructure as code such as Terraform or CloudFormation, and CI/CD pipelines such as GitHub Actions.
Orchestration Systems: Experience with orchestration tools such as Flyte, Temporal, Airflow, Prefect, or similar systems.
Experience building laboratory, scientific workflow, LIMS, ELN, data platform, or ML platform products.
Experience designing systems that support auditability, traceability, reproducibility, data provenance, or regulated workflows.

About LILA

Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves.

LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at www.lila.ai.

Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply.

We're All In

Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Information you provide during your application process will be handled in accordance with our Candidate Privacy Policy.

A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.

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Refine Your Search

senior system engineer jobs in san francisco bay area ca

Senior Software Engineer, Scientific System of Record

Senior Structural Engineer / Project Manager

Optics Engineer

Senior Mechanical Engineer – Accelerator Systems

Senior Quality Engineer

Senior Weblogic/DevOps Engineer (Automation & Middleware)

SENIOR ORACLE FINANCIALS ENGINEER - REMOTE WITHIN CALIFORNIA

Senior Construction Project Manager

Sr. Quality Engineer

Network AND Telecommunications Engineer, ON-SITE, Information Technology, Full-Time, Days

Senior Software Engineer - Salesforce

Sr. Engineer: TI DSP / Real-Time Systems & Audio (iRDK)

Senior Software Engineer (Oracle Cloud EPM)

Senior Staff Data Center Operations Engineer, GPU Hardware Architecture

Senior Aerodynamic Engineer (Turbomachinery & Gas Turbines)

Senior Dynamics Engineer (Turbomachinery & Gas Turbines)

Senior Structural Engineer (Turbomachinery & Gas Turbines)

Senior Electrical Engineer

Sr. Product Quality Engineer

Sr. Transmission Line Engineer

I want to receive the latest job alert for senior system engineer in san francisco bay area ca

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