Top 111 Chemist Jobs in San Francisco Ca

Senior/Principal Scientist, Peptide Medicinal Chemistry
Stealth Biotech —San Mateo, CA
- $150,000 - $200,000 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- In-person
- Health insurance
- Dental insurance
Quick Apply
Chemist - Cannabis Lab
Bay Point Laboratories, Inc. —Benicia, CA
- $23 - $25 an hour
- Full-time
- Background check
- Mid-level
- Master's degree
Quick Apply
Analytical Scientist I
Prolific Machines —Emeryville, CA
- $120,000 - $140,000 a year
- Full-time
- Mid-level
- Doctor of Philosophy
- 1 year
- Disability insurance
- Health insurance
Quality Control Analytical Chemist
Medterials, Inc. —San Carlos, CA
- $100,000 - $150,000 a year
- Overtime
- Microsoft Word
- Microsoft Excel
- Bachelor of Science
- Health insurance
- Dental insurance
Quick Apply
9d
Staff Research Associate
University of California San Francisco —San Francisco, CA
- Bachelor of Science
- Bachelor's degree
- Mentoring
Research Scientist, Life Sciences (Chemistry)
Anthropic —San Francisco, CA
- $300,000 - $320,000 a year
- Hybrid work
- 5 years
- Office
- Bachelor's degree
- Parental leave
- Flexible schedule
Associate Scientist Discovery Proteomics
Amgen —South San Francisco, CA
- Mid-level
- Master's degree
- High school diploma or GED
- Disability insurance
- Health insurance
Quality Control Analytical Chemist
MEDTERIALS INC —San Carlos, CA
- $100,000 - $150,000 a year
- Overtime
- Microsoft Excel
- Bachelor of Science
- No experience needed
- Health insurance
- Dental insurance
Quick Apply
9d
Associate Scientist, Analytical Development
Denali Therapeutics —South San Francisco, CA
- $106,000 - $138,000 a year
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Employee stock purchase plan
- Health insurance
FSP Scientist: Synthetic Molecule Analytical Chemistry
Thermo Fisher Scientific —South San Francisco, CA
- $32.89 - $37.20 an hour
- Full-time
- Microsoft Word
- Background check
- Pass drug screening
- Commuter assistance
- Paid parental leave
3d
Associate Scientist, Formulations
Cytokinetics —San Francisco, CA
- $121,500 - $141,750 a year
- Full-time
- Bachelor of Science
- Mid-level
- Analysis skills
- Disability insurance
- Health insurance
12d
Sr Research Associate, FPD
Gilead Sciences —Foster City, CA
- $94,945 - $122,870 a year
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Health insurance
- Dental insurance
10d
Research Associate IV, Attribute Sciences
Codexis Inc —Redwood City, CA
- $110,000 - $125,000 a year
- Full-time
- Bachelor of Science
- Master's degree
- Bachelor's degree
- Wellness program
- Paid parental leave
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Scientist, FPD
Gilead Sciences —Foster City, CA
- $146,540 - $189,640 a year
- Full-time
- Bachelor of Science
- Mid-level
- Bachelor's degree
- Health insurance
- Dental insurance
Senior Research Associate 1 (Contract)
Eikon Therapeutics —Millbrae, CA
- $48 - $58 an hour
- Contract
- Mid-level
- Master's degree
- Bachelor's degree
Quick Apply
Senior Research Associate, Analytical Operations
Gilead Sciences —Foster City, CA
- $94,945 - $122,870 a year
- Full-time
- Mid-level
- Master's degree
- Bachelor's degree
- Health insurance
- Dental insurance
Research Assistant/Research Associate
Frontage Laboratories —Hayward, CA
- $62,400 - $80,000 a year
- Full-time
- Bachelor of Science
- Maintenance
- Bachelor's degree
- Disability insurance
- Health insurance
Quick Apply
Scientist I, Preformulation
Cytokinetics —San Francisco, CA
- $135,000 - $157,500 a year
- Full-time
- Analysis skills
- Doctor of Philosophy
- Senior level
- Disability insurance
- Health insurance
Scientist, Inorganic/Coordination Chemistry
Voya Energy —Hayward, CA
- $160,000 - $180,000 a year
- Full-time
- Research
- Mid-level
- Health insurance
- Dental insurance
Scientist/Sr. Scientist, Computational Chemistry
General Proximity —San Francisco, CA
- Email
- 3 years
- Doctor of Philosophy
- Organizational skills
- Health insurance
- Dental insurance
Quick Apply

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chemist jobs near san francisco ca

Senior/Principal Scientist, Peptide Medicinal Chemistry

Stealth Biotech
San Mateo, CA

Quick Apply

Job Details

Full-time
$150,000 - $200,000 a year

Benefits

Health insurance
Dental insurance
401(k)
Vision insurance

Qualifications

AI models
Project team coordination
Computational research
Teamwork
Automation
High-performance liquid chromatographs
Medicinal chemistry
Doctor of Philosophy
Pharmaceutical analysis
Project delivery management
Leading team collaboration initiatives
Chemistry
Research data analysis
Cross-functional team management
Pharmaceutical research experience
Python
Cross-functional communication
Nuclear magnetic resonance (NMR) spectroscopy
Mass spectrometry
Molecular analysis

Full Job Description

The role

The candidate will lead peptide medicinal chemistry on one or more discovery programs, from hit triage and affinity maturation through developability optimization to candidate selection.

The role carries end-to-end responsibility for the DMTA cycle: defining the design hypothesis, directing synthesis through contract research organizations, interpreting the resulting data, and returning it to the design models. It is a hands-on position that combines individual technical contributions with project leadership. Close collaboration with our AI team is central to the role: translating model output into designs that can be made and tested, returning experimental results in a form the models can learn from, and helping shape what the models are asked to predict next.

Key responsibilities

Design and program leadership

Set and defend the medicinal chemistry strategy for assigned peptide programs, from hits to development candidates.
Drive affinity maturation campaigns.
Optimize developability alongside potency: proteolytic stability, solubility, permeability, half-life extension, and route-of-administration constraints.
Design off-target examination strategies in collaboration with biology and DMPK.
Represent chemistry in portfolio reviews and before the leadership team, with clear go/no-go recommendations and the data supporting them.

DMTA execution, automation, and throughput

Run a high-cadence DMTA cycle: design molecules, prioritize what gets made, and reduce the time from hypothesis to result.
Establish the data discipline that makes the cycle learnable — structured capture of sequences, structures, assay results, and decisions; and feedback to models.

CRO and external management

Own the relationship with peptide synthesis and analytical CROs.
Prepare and review synthesis requests and characterization data.

Working with the platform

Partner with machine-learning colleagues.
Curate the chemistry knowledge on which the platform depends.

Requirements

PhD in organic chemistry, medicinal chemistry, biochemistry, or a closely related field.
Extensive experience in peptide medicinal chemistry within a drug discovery setting, including demonstrated success in affinity maturation and in optimizing ADME and developability properties of peptides.
Strong synthetic and analytical chemistry skills: solid-phase and solution-phase peptide synthesis, macrocyclization chemistries, non-natural and modified building blocks, conjugation, and the analytical methods required to characterize the products (LC-MS, HRMS, NMR, prep-HPLC, chiral and purity analysis).
Experience in a project-leading role — a discovery project or workstream led end to end, with accountability for direction, cross-functional coordination, and outcomes.
High-throughput and automation experience applied to the DMTA cycle — parallel synthesis, high-throughput analytics, and associated data handling.
Fluency in structure-based and property-based design.
Clear scientific communication, both written and verbal, across chemistry, biology, and computational audiences.

Desirable

Working knowledge of agentic workflows.
Experience establishing synthetic and assay workflows from scratch.
Familiarity with computational tools: docking, molecular dynamics, structure prediction, cheminformatics, or scripting in Python.
Experience with peptide half-life extension strategies or with oral peptide delivery.
Track record in a relevant modality — macrocyclic peptides, constrained peptides, peptide–drug conjugates, etc.
Experience taking a peptide program through IND-enabling studies or working with CMC and process chemistry colleagues on scale-up.
Publications, granted patents, or a preclinical or clinical asset you can speak to.

What we offer

Ownership over the chemistry strategy of a young portfolio, and influence over the design platform itself.
A short path from decision to experiment — a small team, short decision paths, and direct access to leadership.
Close, day-to-day exposure to computational and machine-learning approaches to molecular design.
Competitive salary, early-stage equity, and a full benefits package.

About us

We are an early-stage biotechnology company currently in stealth mode. We have developed proprietary machine-learning models and are applying them to our peptide therapeutics pipeline.

Pay: $150,000.00 - $200,000.00 per year

Benefits:

401(k)
Dental insurance
Health insurance
Vision insurance

Work Location: In person

Quick Apply

Refine Your Search

chemist jobs in san francisco ca

Senior/Principal Scientist, Peptide Medicinal Chemistry

Chemist - Cannabis Lab

Analytical Scientist I

Quality Control Analytical Chemist

Staff Research Associate

Research Scientist, Life Sciences (Chemistry)

Associate Scientist Discovery Proteomics

Quality Control Analytical Chemist

Associate Scientist, Analytical Development

FSP Scientist: Synthetic Molecule Analytical Chemistry

Associate Scientist, Formulations

Sr Research Associate, FPD

Research Associate IV, Attribute Sciences

Scientist, FPD

Senior Research Associate 1 (Contract)

Senior Research Associate, Analytical Operations

Research Assistant/Research Associate

Scientist I, Preformulation

Scientist, Inorganic/Coordination Chemistry

Scientist/Sr. Scientist, Computational Chemistry

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