Top 551 Senior principal scientist Jobs in Weston, Ma

Principal Scientist
Sanofi EU —Waltham, MA
- $122,250.00 - $176,583.33 a year
- Master's degree
- Doctor of Philosophy
- Senior level
- Parental leave
13d
Sr Principal Scientist / Associate Director, Biomarker Assay Development Laboratory
Novartis —Cambridge, MA
- $152,600 - $283,400 a year
- Full-time
- Medicine
- Continuous improvement
- Doctor of Philosophy
- Paid parental leave
- Parental leave
Senior / Principal Scientist, Biochemistry
Treeline Biosciences —Watertown, MA
- $158,000 - $184,000 a year
- 5 years
- Doctor of Philosophy
- Mentoring
Quick Apply
Principal Scientist II, Immunology
ModeX Therapeutics, Inc. —Weston, MA
- $207,000 - $222,000 a year
- Management
- 11+ years
- Master's degree
13d
Senior/Principal Scientist, Computational Biology
Cellular Intelligence —Boston, MA
- $150,000 - $225,000 a year
- Full-time
- Computer Science
- 3 years
- Doctor of Philosophy
Senior Principal Scientist, Analytical Sciences
Eli Lilly —Watertown, MA
- $71,250 - $187,000 a year
- Full-time
- 7 years
- Bachelor of Science
- Analysis skills
- Health insurance
- Dental insurance
Research Scientist/Senior Scientist
Silent Spring Institute —Newton, MA
- $105,000 - $225,700 a year
- Email
- US work authorization
- Senior level
- Health insurance
- Dental insurance
Senior Scientist
BPG Bio, Inc —Waltham, MA
- $120,000 - $150,000 a year
- Full-time
- Doctor of Philosophy
- Neurology
- Senior level
Quick Apply
Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)
Novartis —Cambridge, MA
- $126,000 - $261,000 a year
- Full-time
- Hybrid work
- 5 years
- English
- Master's degree
- Health insurance
- 401(k) matching
Senior Principal Scientist / Assoc Director, Oncology Translational Research
Novartis —Cambridge, MA
- $138,600 - $257,400 a year
- Full-time
- 5 years
- Analysis skills
- Doctor of Philosophy
- Health insurance
- 401(k) matching
Senior Director (Senior Principal Scientist), Translational Medicine, Immunology
Merck —Boston, MA
- $286,900 - $451,600 a year
- Full-time
- Medicine
- BC/BE
- Business development
- Paid holidays
- Health insurance
Contract Scientist/Sr. Scientist – Analytical Development (Cell Therapy)
Commonwealth Sciences —Waltham, MA
- Contract
- Bachelor of Science
- Bachelor's degree
- Continuous improvement
Senior Research Scientist –Flammability and Fire Dynamics
FM —Norwood, MA
- $121,000 - $173,000 a year
- Full-time
- Math
- Doctor of Philosophy
- Senior level
- 401(k)
- Tuition reimbursement
Senior Director, Drug Safety & Pharmacovigilance – Development
Klein Hersh International —Boston, MA
- Email
- Medicine
- 5 years
- Contracts
Senior Research Scientist - AI Trainer
DataAnnotation —Lynn, MA
- $50 - $100 an hour
- Part-time
- Remote
- Computer Science
- Writing skills
- English
- Flexible schedule
Quick Apply
Principal Clinical Trial Manager
TransMedics, Inc. —Andover, MA
- $137,100 - $193,700 a year
- Full-time
- Bachelor of Science
- Office
- Master's degree
- Employee stock purchase plan
- Disability insurance
Quick Apply
Sr. Manager, R&D
Getinge —Boston, MA
- $160,000 a year
- Full-time
- Engineering
- Critical & Intensive Care
- Travel
- Commuter assistance
- Disability insurance
13d
Senior Chemist – Water Quality Laboratory (ISO 17025)
Environmental Testing & Research Laboratories —Leominster, MA
- $67,746.50 - $100,000.00 a year
- Full-time
- Master's degree
- Supervising experience
- Bachelor's degree
- Health savings account
- Health insurance
Quick Apply
Senior Principal Toxicologist
Keurig Dr Pepper —Burlington, MA
- $130,700 - $190,000 a year
- Email
- Doctor of Philosophy
- Travel
- Senior level
- Mileage reimbursement
- Paid parental leave
Senior Research Scientist – Battery and Data Center Safety
FM —Norwood, MA
- $121,000 - $173,000 a year
- Full-time
- Math
- Doctor of Philosophy
- Senior level
- 401(k)
- Tuition reimbursement

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senior principal scientist jobs near weston, ma

Principal Scientist

Sanofi EU -
Waltham, MA

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Job Details

$122,250.00 - $176,583.33 a year
13 days ago

Benefits

Parental leave

Qualifications

Advanced cell culture techniques
Technical engineering
Pharmaceutical company experience
Bioreactors
Laboratory management

Full Job Description

Job title: Principal Scientist

Location: Waltham, MA

About the Job

The Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV vectors, lentiviral vectors and cell therapy products. Sanofi is looking for an experienced cell culture development professional with experience in cell therapy process development to join the Genomic Medicine Cell Therapy Process Development Group located in Waltham, MA in the role of Senior Scientist. The Genomic Medicine Cell Therapy Development group within Sanofi operates with the mission to develop robust, scalable, and innovative cell culture processes for Sanofi’s genomic medicine pipeline.

This position is a senior individual contributor embedded within the Upstream Scale-Up Laboratory, responsible for execution of cell culture bioprocesses at pilot and manufacturing scales (200L–2000L). This role serves as a technical cornerstone of the scale-up team, driving process understanding, operational excellence, and cross-functional alignment with downstream Scale-Up Laboratory team and manufacturing organizations. While this position carries no direct people management responsibilities, the incumbent is expected to demonstrate strong technical leadership — guiding peers, influencing process strategy, and serving as a subject matter expert (SME) in upstream bioprocessing. The role operates at the intersection of process science, engineering rigor, and operational execution, requiring both hands-on laboratory proficiency and the strategic mindset to translate bench-scale learnings into robust, scalable processes.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main responsibilities:

Lead scale-up activities from bench scale to pilot scale (200L–2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
Collaborate with process development scientists to translate laboratory findings into scalable, robust manufacturing processes.
Review and approve JSAs written by equipment owners and provide feedback.
Train employees to adopt best practice for safety, efficiency and operational success.
Build robust internal interfaces with the CMC community and promote the adoption of best practices.
Demonstrate expertise in upstream process operations at all scales.
Lead root cause analysis (RCA) investigations for process deviations, equipment failures at pilot scale.
Present findings and/or results to senior management, external stakeholders, and industry leaders at national/international conferences.

About You

Master’s degree in Chemical Engineering, or related discipline with a minimum of 6 years of relevant experience to large-scale bioreactors, or a Ph.D degree with a minimum of 4 years of industry experience related to large-scale bioreactors.
Strong background in cell culture bioreactor operations and scale-up technologies.
Experience in the biotech/pharmaceutical industry within a cell culture role and an excellent understanding of the operational excellence.
Experience with perfusion process operations at various scales.
Understanding of engineering principles related to cell culture process is required.
Ability to lead matrix teams for operations and lab management.

Preferred Qualifications:

Experience managing cross-functional team and initiatives.
Experience in cell culture process development for AAV manufacturing.
Expertise in mammalian cell culture and related aspects such as cell metabolism/media optimization, engineering fundamentals on cell culture scale-up/down, cell biology/physiology.
Process automation experience.

Why Choose Us

Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
Help improve the lives of millions of people globally by making drug development quicker and more effective.
Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

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Refine Your Search

senior principal scientist jobs in weston, ma

Principal Scientist

Sr Principal Scientist / Associate Director, Biomarker Assay Development Laboratory

Senior / Principal Scientist, Biochemistry

Principal Scientist II, Immunology

Senior/Principal Scientist, Computational Biology

Senior Principal Scientist, Analytical Sciences

Research Scientist/Senior Scientist

Senior Scientist

Principal Scientist II/Senior Principal Scientist, Modeling & Simulation (Dual Level Posting)

Senior Principal Scientist / Assoc Director, Oncology Translational Research

Senior Director (Senior Principal Scientist), Translational Medicine, Immunology

Contract Scientist/Sr. Scientist – Analytical Development (Cell Therapy)

Senior Research Scientist –Flammability and Fire Dynamics

Senior Director, Drug Safety & Pharmacovigilance – Development

Senior Research Scientist - AI Trainer

Principal Clinical Trial Manager

Sr. Manager, R&D

Senior Chemist – Water Quality Laboratory (ISO 17025)

Senior Principal Toxicologist

Senior Research Scientist – Battery and Data Center Safety

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