Top 257 Senior staff scientist Jobs in Berkeley Ca

Staff / Senior Scientist, Assay Development (Chemistry)
Glyphic Biotechnologies —Berkeley, CA
- $123,000 - $187,575 a year
- Full-time
- Doctor of Philosophy
- Senior level
- 4 years
- Paid parental leave
- Health insurance
Quick Apply
Senior Scientist, Membrane Protein Biochemistry
Amgen —South San Francisco, CA
- $142,518.65 - $192,819.35 a year
- 3 years
- Bachelor's degree
- Doctor of Philosophy
- Disability insurance
- Health insurance
Sr Scientist – Immunology
3T Biosciences —South San Francisco, CA
- $145,000 - $165,000 a year
- Master's degree
- Doctor of Philosophy
- Organizational skills
- Paid time off
Senior Scientist - Experimental Protein Design for Target Discovery
Amgen —South San Francisco, CA
- $131,028.35 - $177,273.65 a year
- Medicine
- 3 years
- Bachelor's degree
- Disability insurance
- Health insurance
Staff/Senior Staff, Bioinformatics Data Scientist
Rezo Therapeutics —San Francisco, CA
- $180,000 - $260,000 a year
- Full-time
- Writing skills
- 8 years
- Doctor of Philosophy
- Commuter assistance
- Health insurance
Quick Apply
Hydrogeologist - Mid- or Senior Level
Montgomery & Associates —Oakland, CA
- $8,000 - $9,500 a year
- Full-time
- Microsoft Access
- 6 years
- Office
- AD&D insurance
- Disability insurance
Quick Apply
3d
Principal Environmental Professional or Biologist
Onterris —Oakland, CA
- $150,000 - $180,000 a year
- Full-time
- 11+ years
- Master's degree
- Bachelor's degree
Sr Principal, Executive Operations - Ads & Data Platforms
Disney Entertainment and ESPN Product & Technology —San Francisco, CA
- $227,200 - $304,700 a year
- 11+ years
- Bachelor's degree
- Organizational skills
Senior Scientist - siRNA Bioanalysis & Mechanistic Studies
Amgen —South San Francisco, CA
- $143,820.85 - $194,581.15 a year
- Doctoral degree
- 3 years
- Master's degree
- Disability insurance
- Health insurance
Staff + Senior Software Engineer, Inference
Anthropic —San Francisco, CA
- $320,000 - $485,000 a year
- Hybrid work
- Azure
- Office
- AWS
- Parental leave
- Flexible schedule
Front-End Engineer (Senior/ Staff)
Equilibrium Energy —San Francisco Bay Area, CA
- Remote
- Computer Science
- AWS
- APIs
- Health insurance
- Dental insurance
Scientist / Senior Scientist, Structural Biology
Amgen —South San Francisco, CA
- $142,518.65 - $192,819.35 a year
- 3 years
- Bachelor's degree
- Doctor of Philosophy
- Disability insurance
- Health insurance
1d
Life Sciences Operator, Lead
Anthropic —San Francisco, CA
- $300,000 - $320,000 a year
- Hybrid work
- 7 years
- Office
- Bachelor's degree
- Parental leave
- Flexible schedule
6d
Senior+ Software Engineer, Research Tools
Anthropic —San Francisco, CA
- $300,000 - $405,000 a year
- Hybrid work
- 5 years
- Office
- Bachelor's degree
- Parental leave
- Flexible schedule
Senior Principal Scientist: Metabolomics/Cell Therapy Media Development
Genentech —San Francisco, CA
- $143,290 - $266,110 a year
- Online Application
- 5 years
- Doctor of Philosophy
- Mentoring
Senior Staff Machine Learning Engineer, Guest & Host
Airbnb —San Francisco, CA
- $244,000 - $305,000 a year
- Online Application
- Remote
- Mentoring
- US work authorization
- Senior level
Quick Apply
Senior Scientist - Translational Safety & Risk Sciences (TSRS)
Amgen —San Francisco, CA
- $129,228.90 - $174,839.10 a year
- Remote
- Medicine
- 3 years
- Bachelor's degree
- Disability insurance
- Health insurance
SENIOR INDUSTRIAL HYGIENIST
Department of Public Health —Contra Costa County, CA
- $10,630 - $14,203 a month
- Online Application
- Hybrid work
- Travel
- Senior level
- Professional Engineer
Staff Data Scientist, Machine Learning in Epidemiology and Patient Data Products
Valo Health —San Francisco, CA
- $165,000 - $220,000 a year
- Remote
- 5 years
- Doctor of Philosophy
- US work authorization
- Retirement plan
Biologist 2
HDR —Oakland, CA
- $95,638 - $147,555 a year
- Extended hours
- Microsoft Excel
- Microsoft Outlook
- Construction site
- Paid holidays
- Disability insurance

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Staff / Senior Scientist, Assay Development (Chemistry)

Glyphic Biotechnologies
Berkeley, CA

Quick Apply

Job Details

Full-time
$123,000 - $187,575 a year

Benefits

Stock options
Paid parental leave
Health insurance
Dental insurance
Paid time off
Parental leave
Vision insurance

Qualifications

High-performance liquid chromatographs
DNA sequencing
Assay development
Capillary electrophoresis
Cross-functional collaboration
Organic synthesis
Cross-functional communication
Mass spectrometry

Full Job Description

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

We are seeking a Senior or Staff Scientist to join our Assay Development team at a critical stage in platform development. Reporting to the Director of Assay Development, you will be a hands-on expert working at the chemistry-assay interface — developing the chemical methods that enable reliable, high-efficiency sample loading into our expansion assay, and building the novel conjugation, cleavage, and stabilization workflows that power our single-molecule proteome sequencing platform. You will work closely with the Chemistry team to develop sample input methods for new protein and peptide types, including side-chain protection strategies, encoder loading routes, and peptide-from-protein handoff approaches.

The ideal candidate brings deep expertise in peptide chemistry, bioorthogonal and click conjugation strategies, and cleavage chemistry development — with a track record of building new chemical methods for complex, multi-component systems. You combine a synthetic chemist's mechanistic rigor with sensitivity to how chemistry performs inside a demanding multi-cycle assay environment.

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

What you'll do

Expansion assay chemistry & sample loading

Optimize bioconjugation methods for peptide loading into the expansion assay; establish robust, high-efficiency loading protocols that perform reliably across diverse peptide populations and physicochemical characteristics.
Identify, characterize, and optimize peptide labeling during the ProSE sequencing assay, leveraging mechanistic understanding of Edman chemistry and amino acid side-chain reactivity and stability.
Develop reagents and methods to maximize the stability of peptides, DNA, and peptide-DNA chimeras throughout the ProSE sequencing assay.
Partner with the Chemistry team to develop amino acid side-chain protection chemistries.
Evaluate compatibility of new chemistries with existing assay components, reagents, and multi-cycle sequencing conditions.
Evaluate emerging chemistries from the literature and internal pipeline; synthesize and test candidate reagents.

Novel assay chemistry workflows

Design and determine the order of operations for chemical manipulations within the assay workflow — including decisions on when specific steps occur on-bead versus off-bead, and how side-chain protection and deprotection strategies are sequenced relative to assay cycles — to ensure compatibility, efficiency, and analytical interpretability.
Optimize selective cleavage chemistry workflows for use within the sequencing assay.
Optimize for efficiency, selectivity, and compatibility with assay conditions.
Develop stabilization strategies for sensitive assay intermediates and conjugates.
Employ analytical methods — HPLC (RP and IEX), LC-MS/MS, UV-Vis, CE — to characterize conjugation efficiency, adduct identity, purity, and stability of assay intermediates and conjugates.
Characterize and troubleshoot the impact of the chemical steps of multi-cycle workflows.

What you need

Required:

Advanced degree in organic chemistry, chemical biology, biochemistry, or a related field
Industry experience designing multi-step chemical workflows in complex biological systems, including sequencing or determining the order of chemical manipulations across assay conditions.
- MS/PhD with 6+/4+ years of experience (for Senior Scientist)
- MS/PhD with 8+/6+ years of experience (for Staff Scientist)
Demonstrated experience developing site-selective bioconjugation chemistry for native peptides — including N-terminal, C-terminal, and side-chain modification strategies — using click chemistry (CuAAC, SPAAC, IEDDA), NHS-ester coupling, and related bioorthogonal approaches in multi-component peptide systems.
Experience developing multi-step workflows using peptides, oligonucleotides and bioconjugation techniques including in solution and on surfaces.
Proficiency with analytical characterization of complex conjugates and assay intermediates: HPLC (RP and IEX), LC-MS/MS, UV-Vis; demonstrated ability to develop and validate analytical methods for novel chemical entities.
Method-development mindset: history of building and adapting new chemical approaches rather than executing established protocols.
Ability to function as both an independent contributor and a collaborative partner in a cross-functional team environment.
Excellent problem-solving skills and attention to detail.
Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
Ability to thrive in a fast-paced environment with evolving priorities.

Nice to have:

Familiarity with nanopore or single-molecule sequencing chemistry, and the demands it places on assay reagent purity, stability, and uniformity.
Experience with solid-phase peptide synthesis (SPPS), including on-resin modification, selective sidechain deprotection, and non-standard protecting group strategies.
Familiarity with statistical and DOE-based experimental design for chemistry optimization.
Prior experience in an early-stage biotech or tools/diagnostics company.

We're looking for a teammate that:

Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.
Treats obstacles as problems to be creatively solved, not reasons something can't be done.
Applies sound judgment to the best available information, testing, learning, and iterating.
Shares early and directly when assumptions change, results are unclear, or timelines are at risk.

What you can expect from this role

Work environment:

Collaborative culture where your ideas and expertise are valued
Direct impact on product development and company direction

Professional growth:

Learn from a diverse team of world-class scientists and engineers
Contribute to first-of-their kind technologies, high-impact publications, and patents

Compensation

Estimated Base Salary $123,000 - $187,575

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Quick Apply

Refine Your Search

senior staff scientist jobs in berkeley ca

Staff / Senior Scientist, Assay Development (Chemistry)

Senior Scientist, Membrane Protein Biochemistry

Sr Scientist – Immunology

Senior Scientist - Experimental Protein Design for Target Discovery

Staff/Senior Staff, Bioinformatics Data Scientist

Hydrogeologist - Mid- or Senior Level

Principal Environmental Professional or Biologist

Sr Principal, Executive Operations - Ads & Data Platforms

Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

Staff + Senior Software Engineer, Inference

Front-End Engineer (Senior/ Staff)

Scientist / Senior Scientist, Structural Biology

Life Sciences Operator, Lead

Senior+ Software Engineer, Research Tools

Senior Principal Scientist: Metabolomics/Cell Therapy Media Development

Senior Staff Machine Learning Engineer, Guest & Host

Senior Scientist - Translational Safety & Risk Sciences (TSRS)

SENIOR INDUSTRIAL HYGIENIST

Staff Data Scientist, Machine Learning in Epidemiology and Patient Data Products

Biologist 2

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