Top 1220 Staff scientist Jobs in Castro Valley Ca

Staff / Senior Scientist, Assay Development (Chemistry)
Glyphic Biotechnologies —Berkeley, CA
- $123,000 - $187,575 a year
- Full-time
- Doctor of Philosophy
- Senior level
- 4 years
- Paid parental leave
- Health insurance
Quick Apply
Staff / Senior Scientist, Bioconjugation Chemistry
Glyphic Biotechnologies —Berkeley, CA
- $123,000 - $187,575 a year
- Full-time
- Doctor of Philosophy
- Senior level
- 4 years
- Paid parental leave
- Health insurance
Quick Apply
Perfusionist
University of California San Francisco —San Francisco, CA
- Weekends as needed
- Anatomy knowledge
- Surgery
- BLS Certification
4d
Materials Scientist Department Lead
McCampbell Analytical, Inc., —Pittsburg, CA
- $80,000 - $100,000 a year
- Full-time
- Management
- Bachelor of Science
- Mid-level
- Health insurance
- 401(k)
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Project Geotechnical Engineer
Geocon Consultants, Inc. —Livermore, CA
- $100,000 - $150,000 a year
- Full-time
- Hybrid work
- Background check
- 5 years
- Writing skills
- Paid training
- Health savings account
Quick Apply
Lab Technician - Mechanical Sample Preparation
JH Technologies, Inc. —Fremont, CA
- $60,000 - $80,000 a year
- Full-time
- Customer service
- Analysis skills
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
10d
Staff Clinical Laboratory Scientist
Machaon Diagnostics —Berkeley, CA
- $50 - $100 an hour
- 8 hour shift
- Laboratory experience
- Bachelor's degree
- In-person
- Profit sharing
- Health insurance
Quick Apply
Senior IP Attorney
ASML —San Jose, CA
- $160,125 - $240,188 a year
- Extended hours
- Hybrid work
- Microsoft Word
- Microsoft Outlook
- English
- Paid holidays
- Health insurance
2d
Principal Environmental Professional or Biologist
Onterris —Oakland, CA
- $150,000 - $180,000 a year
- Full-time
- 11+ years
- Master's degree
- Bachelor's degree
Postdoctoral Scholar, Coastal Image Analysis and Modeling - NOAA/USGS, San Francisco
Greater Farallones Association —San Francisco, CA
- $75,000 - $80,000 a year
- Email
- Hybrid work
- Background check
- Clean driving record
- Computer Science
- Health insurance
- Dental insurance
Quick Apply
1d
Construction Materials Testing Technician Level I/II
Kleinfelder Inc —Hayward, CA
- $25 - $33 an hour
- Full-time
- Construction site
- Heavy equipment operation
- Mid-level
- Health savings account
- Paid holidays
Environmental Planner - CEQA in Northern CA
SWCA Environmental Consultants —San Francisco, CA
- $101,861 - $149,485 a year
- Online Application
- Research
- 8 years
- Driver's License
- Employee stock ownership plan
- Opportunities for advancement
Lead, Senior, or Principal Biologist
SWCA Environmental Consultants —Half Moon Bay, CA
- $97,344 - $166,133 a year
- Online Application
- Master's degree
- 8 years
- Bachelor's degree
- Employee stock ownership plan
- Opportunities for advancement
Staff Engineer, Downstream Process Development and Manufacturing
Bioethic Consulting LLC —San Carlos, CA
- $186,000 - $218,000 a year
- Master's degree
- 8 years
- Analysis skills
Quick Apply
1d
FSP Associate Scientist: Synthetic Molecule Pharmaceutics
Thermo Fisher Scientific —South San Francisco, CA
- $32.89 - $38.00 an hour
- Full-time
- Mid-level
- Math
- Team management
- Commuter assistance
- Paid parental leave
3d
Clinical Laboratory Scientist (12 month contract)
Lighthouse Lab Services —Richmond, CA
- $55 - $65 an hour
- Contract
- Mid-level
- Analysis skills
- Bachelor's degree
- Dental insurance
- 401(k) 4% Match
Quick Apply
11d
Staff Scientist II - Medicinal Chemistry
Protagonist Therapeutics —Newark, CA
- $135,000 - $145,000 a year
- Full-time
- Doctor of Philosophy
- Pediatrics
- Organizational skills
Quick Apply
7d
Staff Data Scientist, Firefox
Mozilla —San Francisco, CA
- $163,000 - $218,000 a year
- Remote
- 8 years
- SQL
- Analysis skills
- Paid parental leave
- AD&D insurance
Quick Apply
Staff Scientist, Bioinformatics
Thermo Fisher Scientific —Pleasanton, CA
- $129,400 - $165,000 a year
- Full-time
- Background check
- 6 years
- Office
- Commuter assistance
- Paid parental leave
Staff AI Scientist - Credit Karma
Intuit —Oakland, CA
- $209,500 - $283,500 a year
- 7 years
- Computer Science
- Java

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Staff / Senior Scientist, Assay Development (Chemistry)

Glyphic Biotechnologies
Berkeley, CA

Quick Apply

Job Details

Full-time
$123,000 - $187,575 a year

Benefits

Stock options
Paid parental leave
Health insurance
Dental insurance
Paid time off
Parental leave
Vision insurance

Qualifications

High-performance liquid chromatographs
DNA sequencing
Assay development
Capillary electrophoresis
Cross-functional collaboration
Organic synthesis
Cross-functional communication
Mass spectrometry

Full Job Description

About Glyphic:

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

We are seeking a Senior or Staff Scientist to join our Assay Development team at a critical stage in platform development. Reporting to the Director of Assay Development, you will be a hands-on expert working at the chemistry-assay interface — developing the chemical methods that enable reliable, high-efficiency sample loading into our expansion assay, and building the novel conjugation, cleavage, and stabilization workflows that power our single-molecule proteome sequencing platform. You will work closely with the Chemistry team to develop sample input methods for new protein and peptide types, including side-chain protection strategies, encoder loading routes, and peptide-from-protein handoff approaches.

The ideal candidate brings deep expertise in peptide chemistry, bioorthogonal and click conjugation strategies, and cleavage chemistry development — with a track record of building new chemical methods for complex, multi-component systems. You combine a synthetic chemist's mechanistic rigor with sensitivity to how chemistry performs inside a demanding multi-cycle assay environment.

This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

What you'll do

Expansion assay chemistry & sample loading

Optimize bioconjugation methods for peptide loading into the expansion assay; establish robust, high-efficiency loading protocols that perform reliably across diverse peptide populations and physicochemical characteristics.
Identify, characterize, and optimize peptide labeling during the ProSE sequencing assay, leveraging mechanistic understanding of Edman chemistry and amino acid side-chain reactivity and stability.
Develop reagents and methods to maximize the stability of peptides, DNA, and peptide-DNA chimeras throughout the ProSE sequencing assay.
Partner with the Chemistry team to develop amino acid side-chain protection chemistries.
Evaluate compatibility of new chemistries with existing assay components, reagents, and multi-cycle sequencing conditions.
Evaluate emerging chemistries from the literature and internal pipeline; synthesize and test candidate reagents.

Novel assay chemistry workflows

Design and determine the order of operations for chemical manipulations within the assay workflow — including decisions on when specific steps occur on-bead versus off-bead, and how side-chain protection and deprotection strategies are sequenced relative to assay cycles — to ensure compatibility, efficiency, and analytical interpretability.
Optimize selective cleavage chemistry workflows for use within the sequencing assay.
Optimize for efficiency, selectivity, and compatibility with assay conditions.
Develop stabilization strategies for sensitive assay intermediates and conjugates.
Employ analytical methods — HPLC (RP and IEX), LC-MS/MS, UV-Vis, CE — to characterize conjugation efficiency, adduct identity, purity, and stability of assay intermediates and conjugates.
Characterize and troubleshoot the impact of the chemical steps of multi-cycle workflows.

What you need

Required:

Advanced degree in organic chemistry, chemical biology, biochemistry, or a related field
Industry experience designing multi-step chemical workflows in complex biological systems, including sequencing or determining the order of chemical manipulations across assay conditions.
- MS/PhD with 6+/4+ years of experience (for Senior Scientist)
- MS/PhD with 8+/6+ years of experience (for Staff Scientist)
Demonstrated experience developing site-selective bioconjugation chemistry for native peptides — including N-terminal, C-terminal, and side-chain modification strategies — using click chemistry (CuAAC, SPAAC, IEDDA), NHS-ester coupling, and related bioorthogonal approaches in multi-component peptide systems.
Experience developing multi-step workflows using peptides, oligonucleotides and bioconjugation techniques including in solution and on surfaces.
Proficiency with analytical characterization of complex conjugates and assay intermediates: HPLC (RP and IEX), LC-MS/MS, UV-Vis; demonstrated ability to develop and validate analytical methods for novel chemical entities.
Method-development mindset: history of building and adapting new chemical approaches rather than executing established protocols.
Ability to function as both an independent contributor and a collaborative partner in a cross-functional team environment.
Excellent problem-solving skills and attention to detail.
Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
Ability to thrive in a fast-paced environment with evolving priorities.

Nice to have:

Familiarity with nanopore or single-molecule sequencing chemistry, and the demands it places on assay reagent purity, stability, and uniformity.
Experience with solid-phase peptide synthesis (SPPS), including on-resin modification, selective sidechain deprotection, and non-standard protecting group strategies.
Familiarity with statistical and DOE-based experimental design for chemistry optimization.
Prior experience in an early-stage biotech or tools/diagnostics company.

We're looking for a teammate that:

Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.
Treats obstacles as problems to be creatively solved, not reasons something can't be done.
Applies sound judgment to the best available information, testing, learning, and iterating.
Shares early and directly when assumptions change, results are unclear, or timelines are at risk.

What you can expect from this role

Work environment:

Collaborative culture where your ideas and expertise are valued
Direct impact on product development and company direction

Professional growth:

Learn from a diverse team of world-class scientists and engineers
Contribute to first-of-their kind technologies, high-impact publications, and patents

Compensation

Estimated Base Salary $123,000 - $187,575

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

Quick Apply

Refine Your Search

staff scientist jobs in castro valley ca

Staff / Senior Scientist, Assay Development (Chemistry)

Staff / Senior Scientist, Bioconjugation Chemistry

Perfusionist

Materials Scientist Department Lead

Project Geotechnical Engineer

Lab Technician - Mechanical Sample Preparation

Staff Clinical Laboratory Scientist

Senior IP Attorney

Principal Environmental Professional or Biologist

Postdoctoral Scholar, Coastal Image Analysis and Modeling - NOAA/USGS, San Francisco

Construction Materials Testing Technician Level I/II

Environmental Planner - CEQA in Northern CA

Lead, Senior, or Principal Biologist

Staff Engineer, Downstream Process Development and Manufacturing

FSP Associate Scientist: Synthetic Molecule Pharmaceutics

Clinical Laboratory Scientist (12 month contract)

Staff Scientist II - Medicinal Chemistry

Staff Data Scientist, Firefox

Staff Scientist, Bioinformatics

Staff AI Scientist - Credit Karma

I want to receive the latest job alert for staff scientist in castro valley ca

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