Top 992 Lab Jobs in Cupertino, Ca

Senior Scientist/Principal Scientist, Regulatory T-cell Immunology
Sift Biosciences —San Carlos, CA
- $130,000 - $160,000 a year
- Full-time
- 5 years
- Master's degree
- Bachelor's degree
- Commuter assistance
- Health insurance
Quick Apply
5d
Clinical Laboratory Scientist (Hematology)
Ascend Clinical —Sunnyvale, CA
- $55 - $65 an hour
- Part-time
- Analysis skills
- Organizational skills
- Computer skills
- Paid holidays
- Disability insurance
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Temp to Permanent Entry-Level Data Manager/Clinical Research Coordinator Associate
Stanford University Department of Bioengineering —Stanford, CA
- $35 - $38 an hour
- Temporary
- Bachelor of Science
- HIPAA
- University
Quick Apply
8d
PCB Lab Technician
Gorilla Circuits —San Jose, CA
- $20 - $27 an hour
- Full-time
- Mid-level
- In-person
- Manufacturing
- Health insurance
- Dental insurance
Quick Apply
14d
Dry Lab Associate 1st shift - 90 Day Increase Eligible
TTM Technologies —San Jose, CA
- $41,818 - $66,100 a year
- Full-time
- High school diploma or GED
- Manufacturing
- Entry level
- Health savings account
- Paid holidays
Chemistry Lab Analyst (ICP-MS)
Ascend Clinical —Sunnyvale, CA
- $30 - $32 an hour
- Full-time
- Mid-level
- Math
- Cleaning
- Paid holidays
- Disability insurance
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Lab Technician - 1.0 FTE, Day 8 HRS
Stanford Health Care —Palo Alto, CA
- $42.51 - $47.67 an hour
- Full-time
- Hospital
- Word processing
- Computer literacy
Laboratory Technician
NVIGEN —Sunnyvale, CA
- High school diploma or GED
- Bachelor's degree
- Organizational skills
Lab Technician (Non-Rep) - 1.0 FTE - Night, 8 hrs
Stanford Health Care —Palo Alto, CA
- $42.96 - $48.38 an hour
- Full-time
- Hospital
- Word processing
- Writing skills
Histology Laboratory Manager
Lighthouse Lab Services —Santa Clara, CA
- $110,000 - $140,000 a year
- Monday to Friday
- Analysis skills
- Supervising experience
- Senior level
- Health insurance
- Dental insurance
Quick Apply
Quality Control Inspector
NOEL TECHNOLOGIES —Campbell, CA
- $24 - $29 an hour
- Full-time
- Background check
- Microsoft Outlook
- Mid-level
- Health insurance
- 401(k)
Quick Apply
Quality Assurance/Quality Control
Nippon Trends Food Service, Inc. —San Jose, CA
- $23 - $24 an hour
- Overnight shift
- Microsoft Excel
- Ability to walk for extended periods
- Mid-level
- Health insurance
- Dental insurance
Quick Apply
Quality Assurance Specialist
Bay Area Compliance Laboratories, Corp. —Sunnyvale, CA
- $33 - $38 an hour
- Full-time
- Management
- Laboratory experience
- English
- Health savings account
- Paid holidays
Quick Apply
R&D Technician
PEAK Technical Services Inc. —San Jose, CA
- $25.44 - $57.24 an hour
- Evening shift
- Microsoft Office
- High school diploma or GED
- Assembly
- Health insurance
- Dental insurance
Quick Apply
1d
Medical Laboratory Scientist
Ghost Rx —Palo Alto, CA
- $60 an hour
- Full-time
- Bachelor's degree
- In-person
- 1 year
- Health insurance
- Dental insurance
Quick Apply
Lab Associate 1
Intuitive Surgical —Sunnyvale, CA
- $23 - $37 an hour
- Day shift
- Microsoft Outlook
- Surgery
- Office
- COVID-19 protective measures
4d
Lab Manager / Associate (Entry Level)
BridGene Biosciences, Inc. —San Jose, CA
- $60,000 - $80,000 a year
- Email
- School experience
- Bachelor of Science
- Bachelor's degree
- Health insurance
- Dental insurance
Quick Apply
11d
Lab Assistant III - 1.0 FTE, Day 8 HRS
Stanford Health Care —Palo Alto, CA
- $36.73 - $41.19 an hour
- Full-time
- Hospital
- No experience needed
- English
Materials Technician
Carbon, Inc. —Sunnyvale, CA
- $28.99 - $37.64 an hour
- High school diploma or GED
- In-person
- Associate's degree
Clinical Laboratory Associate
Guardant Health —Redwood City, CA
- $32 - $52 an hour
- Email
- Hybrid work
- Background check
- Office
- Ability to sit for extended periods

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Senior Scientist/Principal Scientist, Regulatory T-cell Immunology

Sift Biosciences
San Carlos, CA

Quick Apply

Job Details

Full-time
$130,000 - $160,000 a year
5 days ago

Benefits

Commuter assistance
Health insurance
Dental insurance
401(k)
Paid time off
Parental leave
Vision insurance
Flexible schedule

Qualifications

Advanced cell culture techniques
Assay development
Cell Biology
Master's degree
Bachelor's degree
Doctor of Philosophy
Immunology
Managing projects
Pre-clinical studies in drug product development
Oncology

Full Job Description

Senior Scientist/Principal Scientist, Regulatory T-cell Immunology

Sift Bio is building a cutting-edge proprietary platform that combines AI, metagenomics, and high-throughput T-cell screening to discover epitopes that drastically amplify pre-existing immune memory responses, unlocking targeted, effective, and safe treatment for cancers and autoimmune diseases where current therapies fall short. Spinning out of UC Berkeley, the Sift Bio team brings together AI-driven discovery and deep translational immunology, with a proven track record of advancing novel immunotherapies from early concept through IND-enabling development. Collectively, the team has built and scaled high-throughput discovery platforms and led T-cell, peptide, and cell-based immunotherapy programs across leading academic labs, biotech startups, and biopharma. Merging this experience with proprietary datasets and computational pipelines, Sift Bio is shaping a new frontier in immunotherapy, unlocking the power of pre-existing immunity to create a fundamentally new class of treatments for immune dysfunctions. Our ultimate goal is to bring durable disease control to every patient.

We are seeking a Principal Scientist / Senior Scientist, Regulatory T-Cell Immunology to lead preclinical drug discovery, focusing on exploiting immunosuppressive T-cells to treat autoimmune diseases, cancer, and inflammation. This role will design and direct experiments, engineer novel cell therapies, and guide research strategy, manage project timelines, and collaborate with teams across clinical development, pharmacology, and regulatory affairs. This role will report to CTO and be fully onsite at 733 Industrial Road, San Carlos, CA.

KEY RESPONSIBILITIES:

Build, qualify, troubleshoot, and optimize end-to-end Treg suppression assays, including selection of potency readouts such as proliferation, cytokine production, activation markers, and other functional measures.
Create ex vivo assays that measure how antigen-specific T-cells drive suppression, benchmark findings against competing modalities, and diagnose underperforming Treg expansion programs through rigorous experimental design.
Characterize candidate epitopes using standard cellular, molecular, genetic, and immunological approaches, including antigen-specific Treg detection: tetramer/multimer staining and antigen-driven activation-induced marker (AIM) readouts, with matrix/pool deconvolution design for peptide screening.
Design and direct in vitro, ex vivo, and in vivo studies to evaluate mechanism of action, target biology, therapeutic efficacy, safety, persistence, stability, and suppressive function of candidate epitopes.
Develop and implement multi-parameter flow cytometry panels, functional immune assays, lineage-stability readouts, and disease-relevant models to support target validation, lead selection, and translational decision-making.
Lead external collaborations, CRO studies, and academic partnerships as needed, ensuring scientific rigor, timeline adherence, and data quality.

REQUIRED EXPERIENCE:

PhD in Immunology, Cell Biology, or a related field, plus 5+ years of post-doctoral or industry experience. Alternatively, a Master’s degree with 8 to 10+ years of biotech experience. Job title will commensurate with experience.
Excited by and scientifically driven to overcome complex technical challenges that will contribute to safe treatment for cancers and autoimmune diseases.
Deep hands-on experience with primary human Tregs and peripheral blood mononuclear cells (PBMCs), including working knowledge of best methods for isolation, expansion, and activation of Tregs/PBMCs
Prior experience developing antigen-specific tolerance or Treg-based approaches, peptide, protein, or engineered cell therapy setting, spanning antigen selection through in vivo functional readouts
Strong T-cell biology expertise, with extensive experience characterizing low frequency (<0.1%) CD8 and CD4 responses, and knowledge of how to improve readouts of rare T-cell responses
Knowledge of how to qualify Treg-based assays with known controls, for how to “rank” performance of manipulations -> impact Treg biology, and methods for how to overcome limitations of characterizing rare T-cell populations
Proven ability to contribute to the scientific direction of a project.
Strong written and oral communication skills for technical and non-technical audiences.
Conscientious team member with experience taking and giving constructive feedback.
Must be comfortable with executing lab work full time in a preclinical-stage startup environment, and capable of finding solutions to tough problems with limited resources.

PREFERRED QUALIFICATIONS:

Familiarity with HLA-transgenic mouse models and/or human PBMC xenograft/humanized models, and a clear-eyed view of which models are best suited to readout effects of an antigen-directed tolerance approach
Experience building immunotherapies for oncology or autoimmune disease settings

Sift Bio is pleased to offer competitive:

Medical, Dental, and Vision health plans.
Flexible time off.
Bonus and Equity plans.
Commuter transit benefit.
401(k) retirement plan.

Sift Bio is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind as outlined by applicable laws.

Pay: $130,000.00 - $160,000.00 per year

Benefits:

401(k)
Dental insurance
Flexible schedule
Health insurance
Paid time off
Parental leave
Vision insurance

Application Question(s):

How many years of industry or post-doc experience do you have?
Please tell us about your experience with preclinical drug discovery, focusing on exploiting immunosuppressive T-cells ideally to treat autoimmune diseases, cancer, and inflammation.

Education:

Bachelor's (Required)

Location:

San Carlos, CA 94070 (Preferred)

Ability to Relocate:

San Carlos, CA 94070: Relocate before starting work (Required)

Work Location: In person

Quick Apply

Refine Your Search

lab jobs in cupertino, ca

Senior Scientist/Principal Scientist, Regulatory T-cell Immunology

Clinical Laboratory Scientist (Hematology)

Temp to Permanent Entry-Level Data Manager/Clinical Research Coordinator Associate

PCB Lab Technician

Dry Lab Associate 1st shift - 90 Day Increase Eligible

Chemistry Lab Analyst (ICP-MS)

Lab Technician - 1.0 FTE, Day 8 HRS

Laboratory Technician

Lab Technician (Non-Rep) - 1.0 FTE - Night, 8 hrs

Histology Laboratory Manager

Quality Control Inspector

Quality Assurance/Quality Control

Quality Assurance Specialist

R&D Technician

Medical Laboratory Scientist

Lab Associate 1

Lab Manager / Associate (Entry Level)

Lab Assistant III - 1.0 FTE, Day 8 HRS

Materials Technician

Clinical Laboratory Associate

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