Top 55 Calico Jobs | SimplyHired

Scientist, Peptide Chemistry
CALICO —South San Francisco, CA
- $135,000 - $145,000 a year
- Analysis skills
- Doctor of Philosophy
- Team management
Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling
CALICO —South San Francisco, CA
- $160,000 - $197,000 a year
- 3 years
- Analysis skills
- Doctor of Philosophy
Dishwasher
Calico —Easthampton, MA
- $21 - $28 an hour
- Weekends as needed
- Ability to lift 50 pounds
- Fair chance
- In-person
- Employee discount
Quick Apply
8d
Principal Scientist, Process Chemistry
CALICO —South San Francisco, CA
- $197,000 - $245,000 a year
- 8 years
- Continuous improvement
- Doctor of Philosophy
Head of Peptide Drug Discovery
CALICO —South San Francisco, CA
- $320,000 - $350,000 a year
- Management
- 11+ years
- Doctor of Philosophy
Head, Research
CALICO —South San Francisco, CA
- $314,000 - $360,000 a year
- Medicine
- Management
- 11+ years
Stewardess/Stew
Calico Yacht Charter —Marina del Rey, CA
- From $25 an hour
- Part-time
- Background check
- CPR Certification
- First Aid Certification
Quick Apply
Machine Learning Scientist / Senior Machine Learning Scientist
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Doctor of Philosophy
- In-person
Principal Scientist, Antibody Engineering & Rational Design
CALICO —South San Francisco, CA
- $198,000 - $241,000 a year
- 8 years
- Doctor of Philosophy
- Senior level
Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology
CALICO —South San Francisco, CA
- $95,000 a year
- Analysis skills
- Presentation skills
- Doctor of Philosophy
Team Member/Line cook
Calico Cactus —Saint Augustine, FL
- $16 - $18 an hour
- Part-time
- In-person
- 1 year
- Restaurant
- Health insurance
- Employee discount
Quick Apply
14d
Machine Learning / Senior Machine Learning Scientist / Engineer
CALICO —South San Francisco, CA
- $170,000 - $240,000 a year
- Computer Science
- Analysis skills
- Doctor of Philosophy
Logistics Coordinator
Calico Precision Molding, LLC —Fort Wayne, IN
- $20 - $27 an hour
- Full-time
- Oracle
- Data analysis skills
- Mid-level
- Health savings account
- Health insurance
Quick Apply
Associate Director/Director, In Vivo Physiology
CALICO —South San Francisco, CA
- $215,000 - $265,000 a year
- Management
- Analysis skills
- Doctor of Philosophy
Postdoctoral Fellow, Hahn Lab - Brain Aging
CALICO —South San Francisco, CA
- $95,000 a year
- Local
- Analysis skills
- Presentation skills
Calico Cupboard Café of Anacortes Assistant Baker
Calico Cupboard Café & Bakery of Anacortes —Anacortes, WA
- $18 - $20 an hour
- Part-time
- In person
- Bakery
- US work authorization
- In-person
- 401(k)
- Paid time off
Quick Apply
Postdoctoral Fellow, Jan Lab - Parkinson's Disease
CALICO —South San Francisco, CA
- $95,000 a year
- Analysis skills
- Presentation skills
- Doctor of Philosophy
Senior Director, Contracts, Alliances and Intellectual Property
CALICO —South San Francisco, CA
- $295,000 - $310,000 a year
- Analysis skills
- Bachelor's degree
- Doctor of Philosophy
Data Engineer, Human Cohorts
CALICO —South San Francisco, CA
- $191,000 - $195,000 a year
- Azure
- Computer Science
- Bachelor of Science
Distribution Center/Warehouse Associate
Everfast, Inc. /Calico —Kennett Square, PA
- $16 - $17 an hour
- Full-time
- Basic math
- High school diploma or GED
- US work authorization
- Paid holidays
- Disability insurance
Quick Apply
5d

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Scientist, Peptide Chemistry

CALICO -
South San Francisco, CA

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Job Details

$135,000 - $145,000 a year

Qualifications

Pharmaceutical synthesis
High-performance liquid chromatographs
Simulation modeling (chemistry)
Formulation chemistry
Assay development
Doctor of Philosophy
Cross-functional collaboration
Automated liquid handling systems
Pharmaceutical research
Cross-functional communication
Drug formulation
Nuclear magnetic resonance (NMR) spectroscopy
Molecular analysis

Full Job Description

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

We are seeking a scientist to join our Peptide Chemistry team. In this role, you will drive peptide drug discovery projects that sit at the nexus of empirical medicinal chemistry and Calico’s proprietary Machine Learning (ML) peptide design platform. You will collaborate cross-functionally with ML scientists, medicinal chemists, automation specialists, and biologists to explore structure-activity relationships (SAR). By leveraging a rapid design-make-test cycle, you will accelerate the optimization of therapeutic peptides and contribute to the evolution of a world-class synthetic engine.

Key Responsibilities:

Drive Discovery: Lead peptide drug discovery campaigns from initial hit identification through to IND-enabling studies
Innovate Synthetic Workflows: Onboard and optimize novel chemistries for high-throughput, automated peptide synthesis; troubleshoot complex synthetic challenges to generate high-quality leads, and curate a custom library of building blocks
Cross-Functional Partnership: Collaborate with biology, software, automation, assay, and pharmacology teams to ensure seamless execution of ML platform objectives and drug discovery milestones
Mentorship and Management: Actively mentor junior scientists, fostering a culture of technical excellence, continuous learning, and collaborative innovation
Manage external collaborations and CROs efficiently, including teams of chemists, DMPK scientists and formulation experts

Position Requirements:

Ph.D. in Organic Chemistry, Peptide Chemistry, or a related discipline with 0-2 years of industry experience in drug discovery
Experience in peptide hit discovery, SAR campaigns, ADMET optimization, and peptide formulation
Proven experience building and interpreting complex assay cascades, including biophysical characterization, functional protein/cell-based assays, and ADMET screening
High proficiency in automated synthesis, purification (HPLC, Flash, SPE), and characterization (LCMS, NMR, CD, etc.)
Demonstrated ability to implement diverse chemistries, including backbone-modifications, macrocyclization, stapling, and bioconjugation via solid- or solution-phase strategies
Excellent problem-solving and analytical skills
Exceptional interpersonal and communication skills for effective collaboration across diverse functional groups
Must be willing to work onsite 5 days per week

Nice to Have:

Experience with organic synthesis, including transition metal catalysis and synthesis of non-canonical amino acids, is highly desired
Experience with automation, software, and data-science integration into chemistry workflows
Ability to utilize AI-tools to improve efficiency of research and build programs for data analysis or synthesis
Knowledgeable on the key principles of ML-design for peptide therapeutics
Prior experience with peptide-specific computational tools for hit discovery, SAR prioritization, molecular modeling, and physicochemical characterization

The estimated base salary range for this role is $135,000 - $145,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Apply Now

Refine Your Search

calico jobs

Scientist, Peptide Chemistry

Scientist/Senior Scientist, Advanced Microscopy and Spatial Profiling

Dishwasher

Principal Scientist, Process Chemistry

Head of Peptide Drug Discovery

Head, Research

Stewardess/Stew

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Principal Scientist, Antibody Engineering & Rational Design

Postdoctoral Fellow, Nile Lab - Ubiquitin/UBL Chemical Biology

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Machine Learning / Senior Machine Learning Scientist / Engineer

Logistics Coordinator

Associate Director/Director, In Vivo Physiology

Postdoctoral Fellow, Hahn Lab - Brain Aging

Calico Cupboard Café of Anacortes Assistant Baker

Postdoctoral Fellow, Jan Lab - Parkinson's Disease

Senior Director, Contracts, Alliances and Intellectual Property

Data Engineer, Human Cohorts

Distribution Center/Warehouse Associate

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